ETS2

ETS2
Cấu trúc được biết đến
PDB	Tìm trên Human UniProt: PDBe RCSB
Danh sách mã id PDB
	4BQA, 4MHV
Mã định danh
Danh pháp	ETS2, ETS2IT1, ETS proto-oncogene 2, transcription factor
ID ngoài	OMIM: 164740 HomoloGene: 3838 GeneCards: ETS2
Mẫu hình biểu hiện RNA
	; ;
	Thêm nguồn tham khảo về sự biểu hiện
Bản thể gen
Chức năng phân tử	• DNA binding; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001948, GO:0016582 protein binding; • glucocorticoid receptor binding; • protein domain specific binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Thành phần tế bào	• Màng tế bào; • Chất nhân; • nhân tế bào; • cytosol;
Quá trình sinh học	• skeletal system development; • biệt hóa tế bào; • GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • ectodermal cell fate commitment; • mesoderm development; • primitive streak formation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Nguồn: Amigo / QuickGO
Gen cùng nguồn
	2114
	n/a
	ENSG00000157557
	n/a
	P15036
	n/a
	NM_001256295; NM_005239
	n/a
	NP_001243224; NP_005230
	n/a
	Wikidata
Xem/Sửa Người

Protein C-ets-2 là một loại protein mà ở người được mã hóa bởi gen ETS2.^[2]^[3] Protein được mã hóa bởi gen này thuộc họ các yếu tố phiên mã.^[2]

Tương tác

ETS2 đã được hiển thị để tương tác với:

Tham khảo

^ “Human PubMed Reference:”.
^ ^a ^b Dwyer J, Li H, Xu D, Liu JP (tháng 10 năm 2007). “Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family”. Annals of the New York Academy of Sciences. 1114 (1): 36–47. doi:10.1196/annals.1396.022. PMID 17986575.
^ “Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)”.
^ ^a ^b Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (tháng 10 năm 1997). “The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner”. The Journal of Biological Chemistry. 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. PMID 9334186.
^ Kasten M, Giordano A (tháng 4 năm 2001). “Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity”. Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931.
^ Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP (tháng 2 năm 1992). “Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter”. Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1291–5. doi:10.1073/pnas.89.4.1291. PMC 48435. PMID 1741383.
^ Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). “Ets-2 interacts with co-repressor BS69 to repress target gene expression”. Anticancer Research. 23 (3A): 2173–8. PMID 12894593.

Đọc thêm

Boulukos KE, Pognonec P, Sariban E, Bailly M, Lagrou C, Ghysdael J (tháng 3 năm 1990). “Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators”. Genes & Development. 4 (3): 401–9. doi:10.1101/gad.4.3.401. PMID 2186967.
Watson DK, Mavrothalassitis GJ, Jorcyk CL, Smyth FE, Papas TS (tháng 10 năm 1990). “Molecular organization and differential polyadenylation sites of the human ETS2 gene”. Oncogene. 5 (10): 1521–7. PMID 2250910.
Watson DK, McWilliams MJ, Lapis P, Lautenberger JA, Schweinfest CW, Papas TS (tháng 11 năm 1988). “Mammalian ets-1 and ets-2 genes encode highly conserved proteins”. Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 7862–6. doi:10.1073/pnas.85.21.7862. PMC 282297. PMID 2847145.
Watson DK, McWilliams-Smith MJ, Nunn MF, Duesberg PH, O'Brien SJ, Papas TS (tháng 11 năm 1985). “The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active”. Proceedings of the National Academy of Sciences of the United States of America. 82 (21): 7294–8. doi:10.1073/pnas.82.21.7294. PMC 391330. PMID 2997781.
Le Beau MM, Rowley JD, Sacchi N, Watson DK, Papas TS, Diaz MO (tháng 11 năm 1986). “Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia”. Cancer Genetics and Cytogenetics. 23 (3): 269–74. doi:10.1016/0165-4608(86)90189-5. PMID 3021321.
Fujiwara S, Fisher RJ, Seth A, Bhat NK, Showalter SD, Zweig M, Papas TS (tháng 2 năm 1988). “Characterization and localization of the products of the human homologs of the v-ets oncogene”. Oncogene. 2 (2): 99–103. PMID 3285299.
Sumarsono SH, Wilson TJ, Tymms MJ, Venter DJ, Corrick CM, Kola R, Lahoud MH, Papas TS, Seth A, Kola I (tháng 2 năm 1996). “Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice”. Nature. 379 (6565): 534–7. doi:10.1038/379534a0. PMID 8596630.
Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (tháng 10 năm 1997). “The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner”. The Journal of Biological Chemistry. 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. PMID 9334186.
Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J (tháng 4 năm 1999). “Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1”. The Journal of Biological Chemistry. 274 (18): 12910–6. doi:10.1074/jbc.274.18.12910. PMID 10212281.
Jayaraman G, Srinivas R, Duggan C, Ferreira E, Swaminathan S, Somasundaram K, Williams J, Hauser C, Kurkinen M, Dhar R, Weitzman S, Buttice G, Thimmapaya B (tháng 6 năm 1999). “p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter”. The Journal of Biological Chemistry. 274 (24): 17342–52. doi:10.1074/jbc.274.24.17342. PMID 10358095.
Kilpatrick LM, Kola I, Salamonsen LA (tháng 7 năm 1999). “Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells”. Biology of Reproduction. 61 (1): 120–6. doi:10.1095/biolreprod61.1.120. PMID 10377039.
Rameil P, Lécine P, Ghysdael J, Gouilleux F, Kahn-Perlès B, Imbert J (tháng 4 năm 2000). “IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells”. Oncogene. 19 (17): 2086–97. doi:10.1038/sj.onc.1203542. PMID 10815800.
Park US, Park SK, Lee YI, Park JG, Lee YI (tháng 7 năm 2000). “Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells”. Oncogene. 19 (30): 3384–94. doi:10.1038/sj.onc.1203674. PMID 10918595.
Pastorcic M, Das HK (tháng 11 năm 2000). “Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene”. The Journal of Biological Chemistry. 275 (45): 34938–45. doi:10.1074/jbc.M005411200. PMID 10942770.
Smith JL, Schaffner AE, Hofmeister JK, Hartman M, Wei G, Forsthoefel D, Hume DA, Ostrowski MC (tháng 11 năm 2000). “ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice”. Molecular and Cellular Biology. 20 (21): 8026–34. doi:10.1128/MCB.20.21.8026-8034.2000. PMC 86413. PMID 11027273.
Mullick J, Anandatheerthavarada HK, Amuthan G, Bhagwat SV, Biswas G, Camasamudram V, Bhat NK, Reddy SE, Rao V, Avadhani NG (tháng 5 năm 2001). “Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter”. The Journal of Biological Chemistry. 276 (21): 18007–17. doi:10.1074/jbc.M100671200. PMID 11279115.
Kasten M, Giordano A (tháng 4 năm 2001). “Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity”. Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931.
Ezashi T, Ghosh D, Roberts RM (tháng 12 năm 2001). “Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4”. Molecular and Cellular Biology. 21 (23): 7883–91. doi:10.1128/MCB.21.23.7883-7891.2001. PMC 99954. PMID 11689681.
Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG (tháng 12 năm 2001). “Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver”. Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ (tháng 8 năm 2012). “Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors”. Proceedings of the National Academy of Sciences of the United States of America. 109 (32): 13016–21. doi:10.1073/pnas.1120299109. PMC 3420197. PMID 22826236.

Liên kết ngoài

Drosophila nhọn - Con ruồi tương tác

[1] “Human PubMed Reference:”.

[pmid17986575-2] Dwyer J, Li H, Xu D, Liu JP (tháng 10 năm 2007). “Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family”. Annals of the New York Academy of Sciences. 1114 (1): 36–47. doi:10.1196/annals.1396.022. PMID 17986575.

[3] “Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)”.

[pmid9334186-4] Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (tháng 10 năm 1997). “The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner”. The Journal of Biological Chemistry. 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. PMID 9334186.

[pmid11313931-5] Kasten M, Giordano A (tháng 4 năm 2001). “Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity”. Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931.

[pmid1741383-6] Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP (tháng 2 năm 1992). “Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter”. Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1291–5. doi:10.1073/pnas.89.4.1291. PMC 48435. PMID 1741383.

[pmid12894593-7] Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). “Ets-2 interacts with co-repressor BS69 to repress target gene expression”. Anticancer Research. 23 (3A): 2173–8. PMID 12894593.

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