苏马尼罗

苏马尼罗
臨床資料
其他名稱PNU-95,666
ATC碼
  • 未分配
识别信息
  • (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one
CAS号179386-43-7（
179386-44-8 (maleate)）
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C11H13N3O
摩尔质量203.25 g·mol−1
3D模型（JSmol（英语：JSmol））
  • CN[C@@H]1Cc2cccc3[nH]c(=O)n(C1)c23

苏马尼罗（英語：Sumanirole，研发代号：PNU-95,666）是一种有机化合物，化学式C11H13N3O，能作为多巴胺受體D2的选择性完全激动剂[1]，1997年为帕金森氏病和不寧腿綜合症研发[2][3]。

参考文献

[编辑]
  1. ^ McCall RB, Lookingland KJ, Bédard PJ, Huff RM. Sumanirole, a highly dopamine D2-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. September 2005, 314 (3): 1248–56. PMID 15980060. S2CID 9835081. doi:10.1124/jpet.105.084202. 
  2. ^ Romero AG, et al. Synthesis of the selective D2 receptor agonist PNU-95666E from D-phenylalanine using a sequential oxidative cyclization strategy. Journal of Organic Chemistry. 1997; 62(19):6582.
  3. ^ Weber M, Chang WL, Breier MR, Yang A, Millan MJ, Swerdlow NR. The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats. European Neuropsychopharmacology. March 2010, 20 (6): 421–425. PMC 2864324 可免费查阅. PMID 20346635. doi:10.1016/j.euroneuro.2010.02.011.