16BO133病毒 是嚴重急性呼吸系統綜合症相關冠狀病毒 (SARSr-CoV)的一個病毒株,在韓國 的馬鐵菊頭蝠 中發現,於2019年發表,其基因組 被完整定序,是首個被完整定序的韓國SARSr-CoV病毒株,在SARSr-CoV中屬於SARS-CoV 相關病毒,與其基因組序列相似度為82.8%。
16BO133病毒於2016年在韓國 馬鐵菊頭蝠 的口腔樣本中被發現,此病毒株的基因組 長29075nt 。在SARSr-CoV中,16BO133和2016年發表、自中國吉林 馬鐵菊頭蝠中發現的JTMC15病毒最為接近,基因組核酸序列相似度為98.3%,與其他SARSr-CoV相較之下,這兩個病毒株因爲ORF7b末端的框移突變 而喪失了ORF8 [ 1] [ 2] 。16BO133病毒和SARS-CoV 的基因組核酸序列相似度則為82.8%[ 3] 。
過去雖有其他SARSr-CoV病毒株在韓國被發現(B15-21病毒等),但皆無完整序列定序[ 4] ,16BO133病毒是首個被完整定序的韓國SARSr-CoV病毒株[ 1] 。
截至2021年1月 (2021-01 ) [update] ,SARS-CoV 與相關病毒株的系統發生樹 :
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^ Na EJ, Lee SY, Kim HJ, Oem JK. Comparative genetic analyses of Korean bat coronaviruses with SARS-CoV and the newly emerged SARS-CoV-2. . J Vet Sci. 2021, 22 (1): e12. PMC 7850784 . PMID 33522164 . doi:10.4142/jvs.2021.22.e12 .
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^ 6.0 6.1 Ge, Xing-Yi; Hu, Ben; Shi, Zheng-Li. Bat Coronaviruses. Wang, Lin-Fa (编). Bats and Viruses . Hoboken, NJ: John Wiley & Sons, Inc. 2015-06-26: 127–155. ISBN 978-1-118-81882-4 . doi:10.1002/9781118818824.ch5 (英语) .
^ He, Biao; Zhang, Yuzhen; Xu, Lin; Yang, Weihong; Yang, Fanli; Feng, Yun; Xia, Lele; Zhou, Jihua; Zhen, Weibin; Feng, Ye; Guo, Huancheng. Perlman, S. , 编. Identification of Diverse Alphacoronaviruses and Genomic Characterization of a Novel Severe Acute Respiratory Syndrome-Like Coronavirus from Bats in China . Journal of Virology. 2014-06-15, 88 (12). ISSN 0022-538X . PMC 4054348 . PMID 24719429 . doi:10.1128/JVI.00631-14 (英语) .
^ 8.0 8.1 Lau, Susanna K. P.; Feng, Yun; Chen, Honglin; Luk, Hayes K. H.; Yang, Wei-Hong; Li, Kenneth S. M.; Zhang, Yu-Zhen; Huang, Yi; Song, Zhi-Zhong; Chow, Wang-Ngai; Fan, Rachel Y. Y. Perlman, S. , 编. Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination . Journal of Virology. 2015-10-15, 89 (20). ISSN 0022-538X . PMC 4580176 . PMID 26269185 . doi:10.1128/JVI.01048-15 (英语) .
^ 9.0 9.1 Ge, Xing-Yi; Li, Jia-Lu; Yang, Xing-Lou; Chmura, Aleksei A.; Zhu, Guangjian; Epstein, Jonathan H.; Mazet, Jonna K.; Hu, Ben; Zhang, Wei; Peng, Cheng; Zhang, Yu-Ji. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor . Nature. 2013-11, 503 (7477). Bibcode:2013Natur.503..535G . ISSN 0028-0836 . PMC 5389864 . PMID 24172901 . doi:10.1038/nature12711 (英语) .
^ Yang, Xing-Lou; Hu, Ben; Wang, Bo; Wang, Mei-Niang; Zhang, Qian; Zhang, Wei; Wu, Li-Jun; Ge, Xing-Yi; Zhang, Yun-Zhi; Daszak, Peter; Wang, Lin-Fa. Perlman, S. , 编. Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus . Journal of Virology. 2016-03-15, 90 (6). ISSN 0022-538X . PMC 4810638 . PMID 26719272 . doi:10.1128/JVI.02582-15 (英语) .