3-羟基异丁酸脱氢酶
| 3-羟基异丁酸脱氢酶 | |||||||||||||
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 PDB rendering based on 2gf2. | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | HIBADH; NS5ATP1 | ||||||||||||
| 扩展标识 | 遗传学：608475 鼠基因：1889802 同源基因：15088 GeneCards: HIBADH Gene | ||||||||||||
| EC編號 | 1.1.1.31 | ||||||||||||
| RNA表达模式 | |||||||||||||
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| 更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 11112 | 58875 | |||||||||||
| Ensembl | ENSG00000106049 | ENSMUSG00000029776 | |||||||||||
| UniProt | P31937 | Q99L13 | |||||||||||
| mRNA序列 | NM_152740 | NM_145567 | |||||||||||
| 蛋白序列 | NP_689953 | NP_663542 | |||||||||||
| 基因位置 |
Chr 7: 27.57 – 27.7 Mb |
Chr 6: 52.55 – 52.64 Mb | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
| 3-羟基异丁酸脱氢酶 | |||||||||
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| 3-羟基异丁酸脱氢酶结构（PDB 2gf2） | |||||||||
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| 识别码 | |||||||||
| EC編號 | 1.1.1.31 | ||||||||
| CAS号 | 9028-39-1 | ||||||||
| 数据库 | |||||||||
| IntEnz | IntEnz浏览 | ||||||||
| BRENDA | BRENDA入口 | ||||||||
| ExPASy | NiceZyme浏览 | ||||||||
| KEGG | KEGG入口 | ||||||||
| MetaCyc | 代谢路径 | ||||||||
| PRIAM | 概述 | ||||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 基因本体 | AmiGO / EGO | ||||||||
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3-羟基异丁酸脱氢酶（英語：3-hydroxyisobutyrate dehydrogenase，EC 1.1.1.31（页面存档备份，存于互联网档案馆））是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：
- 3-羟基-2-甲基丙酸 + NAD+ 2-甲基-3-氧代丙酸 + NADH + H+
3-羟基异丁酸脱氢酶主要参与缬氨酸、亮氨酸和异亮氨酸的降解过程。
参考文献
[编辑]- Gerhard DS; Wagner L; Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504. - Hillier LW; Fulton RS; Fulton LA; et al. The DNA sequence of human chromosome 7.. Nature. 2003, 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
- Scherer SW; Cheung J; MacDonald JR; et al. Human chromosome 7: DNA sequence and biology.. Science. 2003, 300 (5620): 767–72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
- Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Toward a complete human genome sequence.. Genome Res. 1999, 8 (11): 1097–108. PMID 9847074. doi:10.1101/gr.8.11.1097.
- Hughes GJ; Frutiger S; Paquet N; et al. Human liver protein map: update 1993.. Electrophoresis. 1994, 14 (11): 1216–22. PMID 8313870. doi:10.1002/elps.11501401181.
- Rougraff PM; Paxton R; Kuntz MJ; et al. Purification and characterization of 3-hydroxyisobutyrate dehydrogenase from rabbit liver.. J. Biol. Chem. 1988, 263 (1): 327–31. PMID 3335502.
- Rougraff PM; Zhang B; Kuntz MJ,; et al. Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases.. J. Biol. Chem. 1989, 264 (10): 5899–903. PMID 2647728.
