5α-二氢孕酮

5α-二氢孕酮
Skeletal formula of 5α-dihydroprogesterone
Ball-and-stick model of the 5α-dihydroprogesterone molecule
IUPAC名
(5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
别名 Allopregnanedione; 5α-Pregnan-3,20-dione
识别
CAS号 566-65-4
PubChem 92810
ChemSpider 83782
SMILES
 
  • [H][C@]34[C@]2([H])CC[C@@]1([H])CC(CC[C@@](C)1[C@]([H])2CC[C@@](C)3[C@@H]([C@@](C)=O)CC4)=O
ChEBI 28952
性质
化学式 C21H32O2
摩尔质量 316.48 g·mol−1
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

5α-二氢孕酮（5α-Dihydroprogesterone，缩写5α-DHP）也称为别孕烷二酮（allopregnanedione）[1]或 5α-孕烷-3,20-二酮（5α-pregnane-3,20-dione）是一种内源性的孕激素和神经甾体，由孕酮合成[2][3]，同时也是由孕酮合成别孕烷醇酮和异孕烷醇酮的代謝中間產物。

另见

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参考文献

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  1. ^ Finn, Deborah A.; Purdy, Robert H. Neuroactive Steroids in Anxiety and Stress. Handbook of Contemporary Neuropharmacology. 2007. doi:10.1002/9780470101001.hcn026. 
  2. ^ Mellon SH. Neurosteroid regulation of central nervous system development. Pharmacol. Ther. October 2007  , 116 (1): 107–24. PMC 2386997 可免费查阅. PMID 17651807. doi:10.1016/j.pharmthera.2007.04.011. 
  3. ^ Guidotti A, Dong E, Matsumoto K, Pinna G, Rasmusson AM, Costa E. The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders. Brain Res. Brain Res. Rev. November 2001  , 37 (1–3): 110–5. PMID 11744079. doi:10.1016/s0165-0173(01)00129-1.