ABT-670

ABT-670
识别信息
  • 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide
CAS号630119-43-6  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C19H23N3O2
摩尔质量325.41 g·mol−1
3D模型（JSmol（英语：JSmol））
  • [O-][n+]1ccccc1C(CC3)CCN3CNC(=O)c(c2)cccc2C
  • InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23) checkY
  • Key:PUMMPCXNEPHBNN-UHFFFAOYSA-N checkY

ABT-670是一种含氮有机化合物，化学式C19H23N3O2，能作为多巴胺受体D4的激动剂，为治疗勃起功能障碍研发[1]。

它可以2-(4-哌啶基)吡啶-N-氧化物盐酸盐、3-甲基苯甲酰胺（維基數據所列：Q83085589）和甲醛为原料合成得到。[1][2]

参考文献

[编辑]
  1. ^ 1.0 1.1 Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, et al. Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. Journal of Medicinal Chemistry. December 2006, 49 (25): 7450–65. PMID 17149874. doi:10.1021/jm060662k. 
  2. ^ Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q. Preparation of piperazinyl, piperidinyl and related acetamides and benzamides as dopamine D4 receptor agonists useful in treating sexual dysfunction. 2003. US20030229094 A1.