ALC-0315是一种合成脂,为油状物质。它是BioNTech和輝瑞的SARS-CoV-2疫苗和BNT162b2疫苗的賦形劑,为脂质纳米颗粒(LNP)的四成分之一,LNP封装并保护了药物中脆弱的有效成分mRNA。[2][3]
在体内pH下,ALC-0315带正电荷,它可以和带负电荷的mRNA相互作用。[4]这些纳米颗粒在体外和体内都可以促进核酸(如寡核苷酸或信使RNA)的吸收。[5][6]
ALC-0315的合成方法如下:
参考文献[编辑]
- ^ 1.0 1.1 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ([C] 1994-2021 ACD/Labs). Retrieved from SciFinder.
- ^ Michael McCoy. Lipids, the unsung COVID-19 vaccine component, Get Investment. Chemical and Engineering News. February 12, 2021.
- ^ Ryan Cross. Without These Lipid Shells, There Would Be No mRNA Vaccines for COVID-19. Chemical & Engineering News. 2021: 16–19. doi:10.47287/cen-09908-feature1.
- ^ Medicines and Healthcare products Regulatory Agency. Public Assessment Report: Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2 (PDF). 11 December 2020 [2021-05-30]. (原始内容 (PDF)存档于2020-12-16).
- ^ mRNA-based therapeutics — developing a new class of drugs (页面存档备份,存于互联网档案馆), Ugur Sahin, Katalin Karikó and Özlem Türeci, Nature Reviews Drug Discovery, 13, 759-780 (2014), doi:10.1038/nrd4278.
- ^ mRNA vaccines — a new era in vaccinology (页面存档备份,存于互联网档案馆), Norbert Pardi, Michael J. Hogan, Frederick W. Porter and Drew Weissman, Nature Reviews Drug Discovery, 17, 261-279 (2018), doi:10.1038/nrd.2017.243.
外部链接[编辑]