SNAPC1

小核RNA激活蛋白复合体，多肽1，43千道尔顿
Small nuclear RNA activating complex, polypeptide 1, 43kDa
小核RNA激活蛋白复合体，多肽1，43千道尔顿; Small nuclear RNA activating complex, polypeptide 1, 43kDa
标识
代号	SNAPC1; PTFgamma; SNAP43
扩展标识	遗传学：600591 鼠基因：1922877 同源基因：2317 GeneCards: SNAPC1 Gene
基因本体论描述
分子功能	· DNA binding;
细胞成分	· nucleoplasm;
生物过程	· regulation of transcription, DNA-dependent; · transcription from RNA polymerase III promoter; · gene expression;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	6617
Ensembl	ENSG00000023608
UniProt	Q16533
mRNA序列	NM_003082
蛋白序列	NP_003073
基因位置	Chr 14:; 62.23 – 62.26 Mb
PubMed查询	[1]
	查; 论; 编;

snRNA激活蛋白复合体第一亚基（英語：snRNA-activating protein complex subunit 1）是一个由人类基因SNAPC1编码的蛋白质^[1]^[2]。

相互作用

SNAPC1能与SNAPC4^[3]、SNAPC3^[3]^[4]和视网膜母细胞瘤蛋白^[5]发生相互作用。

参考文献

^ Maeng JH, Yoon JB. The human PTFgamma/SNAP43 gene: structure, chromosomal location, and identification of a VNTR in 5'-UTR. J Biochem. September 1998, 124 (1): 23–7. PMID 9644240.
^ Entrez Gene: SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa.
^ ^3.0 ^3.1 Ma, B; Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. (United States). February 2001, 276 (7): 5027–35. ISSN 0021-9258. PMID 11056176. doi:10.1074/jbc.M009301200.
^ Henry, R W; Ma B, Sadowski C L, Kobayashi R, Hernandez N. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc. EMBO J. (ENGLAND). Dec 1996, 15 (24): 7129–36. ISSN 0261-4189. PMC 452539 . PMID 9003788.
^ Hirsch, H A; Gu L, Henry R W. The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression. Mol. Cell. Biol. (UNITED STATES). Dec 2000, 20 (24): 9182–91. ISSN 0270-7306. PMC 102176 . PMID 11094070. doi:10.1128/MCB.20.24.9182-9191.2000.

延伸阅读

Henry RW, Sadowski CL, Kobayashi R, Hernandez N. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III. Nature. 1995, 374 (6523): 653–6. PMID 7715707. doi:10.1038/374653a0.
Yoon JB, Roeder RG. Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein. Mol. Cell. Biol. Advances in Molecular and Cell Biology. 1996, 16 (1): 1–9. ISBN 978-0-7623-0143-0. PMC 230972 . PMID 8524284. doi:10.1016/S1569-2558(08)60061-2.
Henry RW, Ma B, Sadowski CL; et al. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc. EMBO J. 1997, 15 (24): 7129–36. PMC 452539 . PMID 9003788.
Ma B, Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. 2001, 276 (7): 5027–35. PMID 11056176. doi:10.1074/jbc.M009301200.
Hirsch HA, Gu L, Henry RW. The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression. Mol. Cell. Biol. 2001, 20 (24): 9182–91. PMC 102176 . PMID 11094070. doi:10.1128/MCB.20.24.9182-9191.2000.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hinkley CS, Hirsch HA, Gu L; et al. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. J. Biol. Chem. 2003, 278 (20): 18649–57. PMID 12621023. doi:10.1074/jbc.M204247200.
Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Gu L, Esselman WJ, Henry RW. Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC. J. Biol. Chem. 2005, 280 (30): 27697–704. PMID 15955816. doi:10.1074/jbc.M503206200.
Rual JF, Venkatesan K, Hao T; et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005, 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.

[pmid9644240-1] Maeng JH, Yoon JB. The human PTFgamma/SNAP43 gene: structure, chromosomal location, and identification of a VNTR in 5'-UTR. J Biochem. September 1998, 124 (1): 23–7. PMID 9644240.

[entrez-2] Entrez Gene: SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa.

[pmid11056176-3] 3.0 ^3.1 Ma, B; Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. (United States). February 2001, 276 (7): 5027–35. ISSN 0021-9258. PMID 11056176. doi:10.1074/jbc.M009301200.

[pmid9003788-4] Henry, R W; Ma B, Sadowski C L, Kobayashi R, Hernandez N. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc. EMBO J. (ENGLAND). Dec 1996, 15 (24): 7129–36. ISSN 0261-4189. PMC 452539 . PMID 9003788.

[pmid11094070-5] Hirsch, H A; Gu L, Henry R W. The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression. Mol. Cell. Biol. (UNITED STATES). Dec 2000, 20 (24): 9182–91. ISSN 0270-7306. PMC 102176 . PMID 11094070. doi:10.1128/MCB.20.24.9182-9191.2000.

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