Spo11

Spo11
識別號
别名	SPO11；, CT35, SPATA43, TOPVIA, initiator of meiotic double stranded breaks, SPO11 initiator of meiotic double stranded breaks, Meiotic recombination, Spo11, Meiotic_Spo11, IPR013048, Spo11, TOPOVIA
外部ID	OMIM：605114 MGI：1349669 HomoloGene：6059 GeneCards：SPO11
基因位置（人类） 染色体 20號染色體[1] 基因座 20q13.31 起始 57,329,803 bp[1] 终止 57,343,994 bp[1]
基因位置（小鼠） 染色体 小鼠2号染色体[2] 基因座 2 H3|2 95.64 cM 起始 172,819,493 bp[2] 终止 172,835,369 bp[2]
基因本體 分子功能 • 金屬離子結合 • 催化活性 • 水解酶活性 • ATP結合 • 血浆蛋白结合 • isomerase activity • DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity • endodeoxyribonuclease activity, producing 3'-phosphomonoesters • DNA结合 細胞組分 • 染色体 • 端粒 • 细胞核 • nuclear chromosome 生物學過程 • protein localization to chromosome • 雌配子发生 • meiotic telomere clustering • male meiosis I • DNA代谢过程 • DNA catabolic process, endonucleolytic • 卵子发生 • homologous chromosome pairing at meiosis • 減數分裂 • synaptonemal complex assembly • 精子发生 • spermatid development • ovarian follicle development • meiotic DNA double-strand break processing • meiotic DNA double-strand break formation • reciprocal meiotic recombination • double-strand break repair involved in meiotic recombination Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	23626	26972
Ensembl	ENSG00000054796	ENSMUSG00000005883
UniProt	Q9Y5K1 Q5TCH6	Q9WTK8
mRNA​序列	​NM_012444 ​NM_198265	NM_001083959 ​NM_001083960 ​NM_012046 ​NM_001305434
蛋白序列	NP_036576 ​NP_937998	NP_001077428 ​NP_001077429 ​NP_001292363 ​NP_036176
基因位置​（UCSC）	Chr 20: 57.33 – 57.34 Mb	Chr 2: 172.82 – 172.84 Mb
PubMed​查找	[3]	[4]
維基數據
檢視/編輯人類 檢視/編輯小鼠

Spo11是人类基因spo11 编码的蛋白质，在真核生物中广泛存在，与古菌基因TopVIA为直系同源体，负责减数第一次分裂前期遺傳重組中DNA的双链断裂的形成^[5][6]。

参考文献

1. GRCh38: Ensembl release 89: ENSG00000054796 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005883 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
5. Vrielynck N, Chambon A, Vezon D, Pereira L, Chelysheva L, De Muyt A, et al. A DNA topoisomerase VI-like complex initiates meiotic recombination. Science. February 2016, 351 (6276): 939–43 [2020-08-29]. Bibcode:2016Sci...351..939V. PMID 26917763. S2CID 206643600. doi:10.1126/science.aad5196. （原始内容存档于2020-07-11）. 
6. Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. February 2016, 351 (6276): 943–9 [2020-08-29]. Bibcode:2016Sci...351..943R. PMID 26917764. S2CID 9445593. doi:10.1126/science.aad5309. （原始内容存档于2020-07-11）.