促卵泡激素受体

Follicle stimulating hormone receptor
促卵泡激素受体
Follicle stimulating hormone receptor; 促卵泡激素受体
	PDB rendering based on 4AY9.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1XWD, 4AY9
标识
代号	FSHR; FSHRO; LGR1; ODG1
扩展标识	遗传学：136435 鼠基因：95583 同源基因：117 IUPHAR: FSH ChEMBL: 2024 GeneCards: FSHR Gene
基因本体论描述
分子功能	· follicle-stimulating hormone receptor activity; · protein binding;
细胞成分	· plasma membrane; · integral to membrane;
生物过程	· G-protein coupled receptor signaling pathway; · spermatogenesis; · female gamete generation; · gonad development; · male gonad development; · female gonad development; · follicle-stimulating hormone signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	2492
Ensembl	ENSG00000170820
UniProt	P23945
mRNA序列	NM_000145
蛋白序列	NP_000136
基因位置	Chr 2:; 49.19 – 49.38 Mb
PubMed查询	[1]
	查; 论; 编;

促卵泡激素受体（英語：follicle-stimulating hormone receptor，FSH receptor，FSHR）是一种在卵巢、子宫和睾丸中发现的G蛋白偶联受体（GPCR），其激活是在繁殖期间的荷尔蒙运作所需的。

FSHR基因

FSHR 基因位于人的2號染色體上p21区，长约2080个核苷酸^[1]。

历史

馬丁·羅德貝爾与艾爾佛列·古曼·吉爾曼因发现G蛋白系统而获得1994年的诺贝尔生理学或医学奖。

另见

黄体生成素/绒毛膜促性腺激素受体

参考文献

^ Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr. Rev. December 1997, 18 (6): 739–73. PMID 9408742. doi:10.1210/er.18.6.739.

延伸阅读

de la Chapelle A. Disease gene mapping in isolated human populations: the example of Finland.. J. Med. Genet. 1993, 30 (10): 857–65. PMC 1016570 . PMID 8230163. doi:10.1136/jmg.30.10.857.
Amsterdam A, Hanoch T, Dantes A; et al. Mechanisms of gonadotropin desensitization.. Mol. Cell. Endocrinol. 2003, 187 (1–2): 69–74. PMID 11988313. doi:10.1016/S0303-7207(01)00701-8.
Simoni M, Nieschlag E, Gromoll J. Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction. Hum. Reprod. Update. 2003, 8 (5): 413–21. PMID 12398222. doi:10.1093/humupd/8.5.413.
Delbaere A, Smits G, Olatunbosun O; et al. New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?. Hum. Reprod. 2004, 19 (3): 486–9. PMC 2891954 . PMID 14998941. doi:10.1093/humrep/deh124.
Bose CK. Role of nerve growth factor and FSH receptor in epithelial ovarian cancer. Reprod. Biomed. Online. 2005, 11 (2): 194–7. PMID 16168216. doi:10.1016/S1472-6483(10)60958-3.
Wunsch A, Sonntag B, Simoni M. Polymorphism of the FSH receptor and ovarian response to FSH. Ann. Endocrinol. (Paris). 2007, 68 (2–3): 160–6. PMID 17544358. doi:10.1016/j.ando.2007.04.006.
Kelton CA, Cheng SV, Nugent NP; et al. The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells. Mol. Cell. Endocrinol. 1993, 89 (1–2): 141–51. PMID 1301382. doi:10.1016/0303-7207(92)90220-Z.
Tilly JL, Aihara T, Nishimori K; et al. Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts. Endocrinology. 1992, 131 (2): 799–806. PMID 1322283. doi:10.1210/en.131.2.799.
Gromoll J, Gudermann T, Nieschlag E. Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor. Biochem. Biophys. Res. Commun. 1992, 188 (3): 1077–83. PMID 1359889. doi:10.1016/0006-291X(92)91341-M.
Minegishi T, Nakamura K, Takakura Y; et al. Cloning and sequencing of human FSH receptor cDNA. Biochem. Biophys. Res. Commun. 1991, 175 (3): 1125–30. PMID 1709010. doi:10.1016/0006-291X(91)91682-3.
Gromoll J, Ried T, Holtgreve-Grez H; et al. Localization of the human FSH receptor to chromosome 2 p21 using a genomic probe comprising exon 10. J. Mol. Endocrinol. 1994, 12 (3): 265–71. PMID 7916967. doi:10.1677/jme.0.0120265.
Gromoll J, Dankbar B, Gudermann T. Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene. Mol. Cell. Endocrinol. 1994, 102 (1–2): 93–102. PMID 7926278. doi:10.1016/0303-7207(94)90102-3.
Rousseau-Merck MF, Atger M, Loosfelt H; et al. The chromosomal localization of the human follicle-stimulating hormone receptor gene (FSHR) on 2p21-p16 is similar to that of the luteinizing hormone receptor gene. Genomics. 1993, 15 (1): 222–4. PMID 8432542. doi:10.1006/geno.1993.1041.
Jiang X, Dreano M, Buckler DR; et al. Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure. 1996, 3 (12): 1341–53. PMID 8747461. doi:10.1016/S0969-2126(01)00272-6.
Aittomäki K, Herva R, Stenman UH; et al. Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene. J. Clin. Endocrinol. Metab. 1996, 81 (10): 3722–6. PMID 8855829. doi:10.1210/jc.81.10.3722.
Tapanainen JS, Aittomäki K, Min J; et al. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nat. Genet. 1997, 15 (2): 205–6. PMID 9020851. doi:10.1038/ng0297-205.
Kotlar TJ, Young RH, Albanese C; et al. A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors. J. Clin. Endocrinol. Metab. 1997, 82 (4): 1020–6. PMID 9100567. doi:10.1210/jc.82.4.1020.

外部链接

Glycoprotein Hormone Receptors: FSH. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2014-04-07）.
GRIS: Glycoprotein-hormone Receptor Information System

[FSHR-1] Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr. Rev. December 1997, 18 (6): 739–73. PMID 9408742. doi:10.1210/er.18.6.739.

[1]