布西丁

布西丁
臨床資料
ATC碼
识别信息
  • N-(4-Ethoxyphenyl)-3-hydroxybutanamide
CAS号1083-57-4  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.012.827 編輯維基數據鏈接
化学信息
化学式C12H17NO3
摩尔质量223.27 g·mol−1
3D模型(JSmol英语JSmol
  • O=C(Nc1ccc(OCC)cc1)CC(O)C
  • InChI=1S/C12H17NO3/c1-3-16-11-6-4-10(5-7-11)13-12(15)8-9(2)14/h4-7,9,14H,3,8H2,1-2H3,(H,13,15)
  • Key:LIAWQASKBFCRNR-UHFFFAOYSA-N

布西丁(英語:Bucetin)是一种曾经用于镇痛退热的药物。[1][2]从化学结构上来看,布西丁和非那西丁相似,并且都有引发癌变的风险。[3]由于其肾毒性,布西丁于1986年被撤回。[4]

参见

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参考资料

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  1. ^ J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 184– [2021-04-12]. ISBN 978-1-4757-2085-3. (原始内容存档于2021-04-12). 
  2. ^ WHOCC - ATC/DDD Index. WHO Collaborating Centre for Drug Statistics Methodology. December 19, 2013 [2021-04-12]. (原始内容存档于2021-01-28). 
  3. ^ Togei K, Sano N, Maeda T, Shibata M, Otsuka H. Carcinogenicity of bucetin in (C57BL/6 X C3H)F1 mice. Journal of the National Cancer Institute. November 1987, 79 (5): 1151–8. PMID 3479641. doi:10.1093/jnci/79.5.1151. 付费文献
  4. ^ Fung M, Thornton A, Mybeck K, Wu JH, Hornbuckle K, Muniz E. Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999. Drug Information Journal. 2001, 35: 293–317. doi:10.1177/009286150103500134. 付费文献