曲喹辛

曲喹辛
IUPAC名
9,10-Dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
识别
CAS号 79855-88-2  checkY
PubChem 5537
ChemSpider 5336
SMILES
 
  • CC1=CC(=C(C(=C1)C)N=C2C=C3C4=CC(=C(C=C4CCN3C(=O)N2C)OC)OC)C
InChI
 
  • 1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3
InChIKey MCMSJVMUSBZUCN-UHFFFAOYSA-N
性质
化学式 C24H27N3O3
摩尔质量 405.49 g·mol−1
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

曲喹辛（英語：Trequinsin，也译为“曲林菌素”）是一种含氮有机化合物，分子式C24H27N3O3，可作为磷酸二酯酶抑制药[1]，在体外实验（in vitro）中能增强精子活性[2]。

参考文献

[编辑]
  1. ^ Whitaker, RM; Wills, LP; Stallons, LJ; Schnellmann, RG. CGMP-Selective Phosphodiesterase Inhibitors Stimulate Mitochondrial Biogenesis and Promote Recovery from Acute Kidney Injury. The Journal of Pharmacology and Experimental Therapeutics. 2013, 347 (3): 626–34. PMC 3836317 可免费查阅. PMID 24042162. doi:10.1124/jpet.113.208017. 
  2. ^ McBrinn, RC; Fraser, J; Hope, AG; Gray, DW; Barratt, CLR; Martins da Silva, SJ; Brown, SG. Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function.. British journal of pharmacology. 2019-12, 176 (23): 4521–4536. PMID 31368510. doi:10.1111/bph.14814.