美地霉素

美地霉素
臨床資料
给药途径口服
ATC碼
识别信息
  • (2S,3S,4R,6S)-6[(2R,3S,4R,5R,6S)-6[(4S,5R,6S,7R,9R,10R,11E,13E,16R)-10-(acetyloxy)-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-4-propoxy-1-oxacyclohexadeca-11,13-dien-6-yl]oxy4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy2,4-dimethyl-3-propoxyoxan-4-yl acetate
CAS号55881-07-7  ☒N
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.054.418 編輯維基數據鏈接
化学信息
化学式C45H75NO15
摩尔质量870.075 g/mol
熔点220 °C(428 °F)
水溶性微溶于,可溶于甲醇丙酮氯仿。 mg/mL (20 °C)

美地霉素又称为“麦加霉素”“美欧卡霉素”“米卡霉素”“乙酰麦迪霉素”或“醋酸麦迪霉素”,是一种大环内酯类抗生素[1] 。美地霉素是麦迪霉素的二乙酸酯,其血药浓度大、生物学半衰期长,较麦迪霉素易吸收。

参考来源

[编辑]
  1. ^ Holliday SM, Faulds D. Miocamycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. Drugs. October 1993, 46 (4): 720–45. PMID 7506653. doi:10.2165/00003495-199346040-00008.