腺苷A3受體

腺苷A3受體
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1OEA、1R7N
識別號
别名	ADORA3；, A3AR, AD026, bA552M11.5, adenosine A3 receptor
外部ID	OMIM：600445 MGI：104847 HomoloGene：550 GeneCards：ADORA3
相關疾病
	肥胖症
為以下藥物的標靶
	腺苷、BAY 60-6583、Regadenoson、CCPA、CGS-21680、cyclopentyladenosine、咖啡因、CGS 15943、8-环戊基-1,3-二丙基黄嘌呤、flavone、高良姜素、istradefylline、尼卡地平、瑞德南特、rolofylline、樱花素、sch-442416、sch-58261、茶碱、ZM-241385、腺苷、namodenoson
基因位置（人类）
染色体	1號染色體
终止	111,503,633 bp
基因位置（小鼠）
染色体	小鼠3号染色体
终止	105,816,242 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• G protein-coupled adenosine receptor activity; • G protein-coupled receptor activity; • signal transducer activity;
細胞組分	• integral component of membrane; • 细胞膜; • 膜; • integral component of plasma membrane;
生物學過程	• G protein-coupled adenosine receptor signaling pathway; • inflammatory response; • 訊息傳遞; • activation of adenylate cyclase activity; • regulation of heart contraction; • response to wounding; • negative regulation of cell population proliferation; • negative regulation of cell migration; • negative regulation of NF-kappaB transcription factor activity; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	140
	11542
	ENSG00000282608
	ENSMUSG00000000562
	P0DMS8
	Q61618,Q3U4C5
	NM_001302679; NM_000677; NM_001302678
	NM_009631
	NP_000668; NP_001289607; NP_001289608
	NP_033761
	維基數據
檢視/編輯人類	檢視/編輯小鼠

腺苷A₃受體(Adenosine A₃ receptor)，也稱為ADORA3，是一種腺苷受體，也表示編碼它的人類基因。

參考資料

^ 與腺苷A3受體相關的疾病；在維基數據上查看/編輯參考.
^ 對Adenosine A3 receptor起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000282608 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000000562 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

延伸閱讀

Klotz KN. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch. Pharmacol. 2001, 362 (4–5): 382–91. PMID 11111832. S2CID 12938732. doi:10.1007/s002100000315.
Monitto CL, Levitt RC, DiSilvestre D, Holroyd KJ. Localization of the A3 adenosine receptor gene (ADORA3) to human chromosome 1p. Genomics. 1995, 26 (3): 637–8. PMID 7607699. doi:10.1016/0888-7543(95)80194-Q.
Salvatore CA, Jacobson MA, Taylor HE, et al. Molecular cloning and characterization of the human A3 adenosine receptor. Proc. Natl. Acad. Sci. U.S.A. 1993, 90 (21): 10365–9. PMC 47775 . PMID 8234299. doi:10.1073/pnas.90.21.10365.
Sajjadi FG, Firestein GS. cDNA cloning and sequence analysis of the human A3 adenosine receptor. Biochim. Biophys. Acta. 1993, 1179 (1): 105–7. PMID 8399349. doi:10.1016/0167-4889(93)90077-3.
Murrison EM, Goodson SJ, Edbrooke MR, Harris CA. Cloning and characterisation of the human adenosine A3 receptor gene. FEBS Lett. 1996, 384 (3): 243–6. PMID 8617363. S2CID 3170758. doi:10.1016/0014-5793(96)00324-9.
Bonaldo MF, Lennon G, Soares MB. Normalization and subtraction: two approaches to facilitate gene discovery. Genome Res. 1997, 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791 .
Bouma MG, Jeunhomme TM, Boyle DL, et al. Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors. J. Immunol. 1997, 158 (11): 5400–8. PMID 9164961.
Atkinson MR, Townsend-Nicholson A, Nicholl JK, et al. Cloning, characterisation and chromosomal assignment of the human adenosine A3 receptor (ADORA3) gene. Neurosci. Res. 1998, 29 (1): 73–9. PMID 9293494. S2CID 36060683. doi:10.1016/S0168-0102(97)00073-4.
Palmer TM, Harris CA, Coote J, Stiles GL. Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor. Mol. Pharmacol. 1997, 52 (4): 632–40. PMID 9380026. doi:10.1124/mol.52.4.632.
Liang BT, Jacobson KA. A physiological role of the adenosine A3 receptor: Sustained cardioprotection. Proc. Natl. Acad. Sci. U.S.A. 1998, 95 (12): 6995–9. PMC 22715 . PMID 9618527. doi:10.1073/pnas.95.12.6995.
Dougherty C, Barucha J, Schofield PR, et al. Cardiac myocytes rendered ischemia resistant by expressing the human adenosine A1 or A3 receptor. FASEB J. 1999, 12 (15): 1785–92. PMC 5550893 . PMID 9837869. doi:10.1096/fasebj.12.15.1785.
Murphy WJ, Eizirik E, Johnson WE, et al. Molecular phylogenetics and the origins of placental mammals. Nature. 2001, 409 (6820): 614–8. PMID 11214319. S2CID 4373847. doi:10.1038/35054550.
Gao ZG, Chen A, Barak D, et al. Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor. J. Biol. Chem. 2002, 277 (21): 19056–63. PMC 5602557 . PMID 11891221. doi:10.1074/jbc.M110960200.
Broussas M, Cornillet-Lefèbvre P, Potron G, Nguyên P. Adenosine inhibits tissue factor expression by LPS-stimulated human monocytes: involvement of the A3 adenosine receptor. Thromb. Haemost. 2003, 88 (1): 123–30. PMID 12152652. doi:10.1055/s-0037-1613164.
Merighi S, Mirandola P, Milani D, et al. Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells. J. Invest. Dermatol. 2002, 119 (4): 923–33. PMID 12406340. doi:10.1046/j.1523-1747.2002.00111.x.
Trincavelli ML, Tuscano D, Marroni M, et al. A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation. Mol. Pharmacol. 2002, 62 (6): 1373–84. PMC 4806643 . PMID 12435805. doi:10.1124/mol.62.6.1373.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors. Circ. Res. 2003, 92 (5): 485–92. PMID 12600879. doi:10.1161/01.RES.0000061572.10929.2D .
Gao ZG, Kim SK, Gross AS, et al. Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor. Mol. Pharmacol. 2003, 63 (5): 1021–31. PMC 4367541 . PMID 12695530. doi:10.1124/mol.63.5.1021.

外部連結

Adenosine Receptors: A₃. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2020-11-30）.
Human ADORA3 genome location and ADORA3 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[1] 與腺苷A3受體相關的疾病；在維基數據上查看/編輯參考.

[2] 對Adenosine A3 receptor起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000282608 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000000562 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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