阿利鲁单抗

阿利鲁单抗
单克隆抗体
种类?
目標整合素α4β7英语LPAM-1
臨床資料
其他名稱AMG 181
ATC碼
  • 未分配
识别信息
CAS号1342290-43-0
ChemSpider
  • none
UNII
KEGG
化学信息
化学式C6362H9806N1686O2014S52
摩尔质量143,803.34 g·mol−1

阿利鲁单抗INN:abrilumab;开发代号:AMG 181)是一种抗α4β7英语LPAM-1单克隆抗体[1]设计用于治疗炎症性肠病[1]溃疡性结肠炎[2]克罗恩病[3]

该药物由安进公司阿斯利康旗下的MedImmune英语MedImmune开发。[4]针对该药物的开发已于2016年停止。[5]

参考资料

[编辑]
  1. ^ 1.0 1.1 Sandborn, William J.; Cyrille, Marcoli; Hansen, Mark Berner; Feagan, Brian G.; Loftus, Edward V.; Rogler, Gerhard; Vermeire, Severine; Cruz, Martha L.; Yang, Jun; Boedigheimer, Michael J.; Abuqayyas, Lubna. Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis. Gastroenterology. 2019-03, 156 (4). ISSN 1528-0012. PMID 30472236. doi:10.1053/j.gastro.2018.11.035. 
  2. ^ Hibi, Toshifumi; Motoya, Satoshi; Ashida, Toshifumi; Sai, Souken; Sameshima, Yukinori; Nakamura, Shiro; Maemoto, Atsuo; Nii, Masahiro; Sullivan, Barbara A.; Gasser, Robert A.; Suzuki, Yasuo. Efficacy and safety of abrilumab, an α4β7 integrin inhibitor, in Japanese patients with moderate-to-severe ulcerative colitis: a phase II study. Intestinal Research. 2019-07, 17 (3). ISSN 1598-9100. PMC 6667363可免费查阅. PMID 30739435. doi:10.5217/ir.2018.00141. 
  3. ^ Pan, Wei-Jian; Köck, Kathleen; Rees, William A; Sullivan, Barbara A; Evangelista, Christine M; Yen, Mark; Andrews, Jane M; Radford-Smith, Graham L; Prince, Peter J; Reynhardt, Kaz O; Doherty, David R. Clinical pharmacology of AMG 181, a gut-specific human anti-α4β7 monoclonal antibody, for treating inflammatory bowel diseases. British Journal of Clinical Pharmacology. 2014-12, 78 (6). ISSN 0306-5251. PMC 4256621可免费查阅. PMID 24803302. doi:10.1111/bcp.12418. 
  4. ^ Abrilumab - Amgen/AstraZeneca - AdisInsight. adisinsight.springer.com. [2024-05-25]. 
  5. ^ abrilumab | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY. www.guidetopharmacology.org. [2024-05-25].