Baccatin III

Baccatin III

Names
IUPAC name (2β,5α,7α,10α,13β)-4,10-Diacetoxy-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Identifiers
CAS Number	27548-93-2^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:32898
ChEMBL	ChEMBL288043
ChemSpider	23486966
ECHA InfoCard	100.164.451
EC Number	636-675-9
KEGG	C11900
PubChem CID	65366
UNII	40K5PZ0K67^Y
CompTox Dashboard (EPA)	DTXSID301029474
InChI InChI=1S/C31H38O11/c1-15-19(34)13-31(38)26(41-27(37)18-10-8-7-9-11-18)24-29(6,20(35)12-21-30(24,14-39-21)42-17(3)33)25(36)23(40-16(2)32)22(15)28(31,4)5/h7-11,19-21,23-24,26,34-35,38H,12-14H2,1-6H3/t19-,20-,21+,23+,24-,26-,29+,30-,31+/m0/s1 Key: OVMSOCFBDVBLFW-VHLOTGQHSA-N
SMILES CC1=C2[C@@H](C(=O)[C@@]3([C@@H](C[C@H]4[C@]([C@H]3[C@H]([C@@](C2(C)C)(C[C@H]1O)O)OC(=O)c5ccccc5)(CO4)OC(=O)C)O)C)OC(=O)C
Properties
Chemical formula	C31H38O11
Molar mass	586.62677 Da
Melting point	229 to 234 °C (444 to 453 °F; 502 to 507 K)
Acidity (pKa)	12.76
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Baccatin III is an isolate from the yew tree (Genera Taxus). Baccatin III is a precursor to the anti-cancer drug paclitaxel (Taxol).

In 2014, researchers reported introduction and expression of the endophytic fungal gene responsible for synthesizing baccatin III (10-deacetylbaccatin III 10-O-acetyltransferase), to the mushroom Flammulina velutipes.^[1] Researchers achieved the same accomplishment with Escherichia coli in 2000.^[2]

See also

• 10-Deacetylbaccatin
• Taxadiene

References

1. Han F, Kang LZ, Zeng XL, Ye ZW, Guo LQ, Lin JF (2014). "Bioproduction of baccatin III, an advanced precursor of paclitaxol with transgenic Flammulina velutipes expressing 10-Deacetylbaccatin III-10-O-acetyl transferase gene". J Sci Food Agric. 94 (12): 2376–2383. Bibcode:2014JSFA...94.2376H. doi:10.1002/jsfa.6562. PMID 24403190.
2. Walker K, Croteau R (2000). "Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli". Proc Natl Acad Sci U S A. 97 (2): 583–7. Bibcode:2000PNAS...97..583W. doi:10.1073/pnas.97.2.583. PMC 15373. PMID 10639122.