CCL13

CCL13
Identifiers
Aliases	CCL13, CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1, C-C motif chemokine ligand 13
External IDs	OMIM: 601391; MGI: 98259; GeneCards: CCL13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RA4
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 34,356,480 bp[1] End 34,358,610 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 C|11 49.82 cM Start 82,035,571 bp[2] End 82,037,453 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad mucosa of transverse colon decidua tibial nerve epithelium of colon tendon of biceps brachii rectum Achilles tendon duodenum right adrenal cortex Top expressed in endothelial cell of lymphatic vessel stroma of bone marrow spermatid embryo cranial nervi trigeminal nerve ophthalmic nerve interventricular septum sciatic nerve inner muscle layer More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity chemokine activity CCR chemokine receptor binding signaling receptor binding protein binding Cellular component extracellular region extracellular space Biological process monocyte chemotaxis cell-cell signaling eosinophil chemotaxis chemotaxis positive regulation of GTPase activity cytoskeleton organization immune response positive regulation of ERK1 and ERK2 cascade regulation of cell shape signal transduction inflammatory response antimicrobial humoral immune response mediated by antimicrobial peptide cellular calcium ion homeostasis neutrophil chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor regulation of signaling receptor activity G protein-coupled receptor signaling pathway cell chemotaxis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 6357 20296 Ensembl ENSG00000181374 ENSMUSG00000035385 UniProt Q99616 P10148 RefSeq (mRNA) NM_005408 NM_011333 RefSeq (protein) NP_005399 NP_035463 Location (UCSC) Chr 17: 34.36 – 34.36 Mb Chr 11: 82.04 – 82.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family. Its gene is located on human chromosome 17 within a large cluster of other CC chemokines.^[5][6] CCL13 induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5.^[7] Activity of this chemokine has been implicated in allergic reactions such as asthma.^[8] CCL13 can be induced by the inflammatory cytokines interleukin-1 and TNF-α.

References

1. GRCh38: Ensembl release 89: ENSG00000181374 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035385 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Garcia-Zepeda EA, et al.. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613–5626
6. Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40.
7. Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.
8. Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32.