CTNNBIP1

CTNNBIP1
Cấu trúc được biết đến
PDB	Tìm trên Human UniProt: PDBe RCSB
Danh sách mã id PDB
	1M1E, 1T08
Mã định danh
Danh pháp	CTNNBIP1, ICAT, catenin beta interacting protein 1
ID ngoài	OMIM: 607758 HomoloGene: 10641 GeneCards: CTNNBIP1
Bản thể gen
Chức năng phân tử	• beta-catenin binding; • GO:0001948, GO:0016582 protein binding; • armadillo repeat domain binding;
Thành phần tế bào	• tế bào chất; • cytosol; • Chất nhân; • nhân tế bào; • beta-catenin destruction complex;
Quá trình sinh học	• negative regulation of smooth muscle cell proliferation; • GO:0106160 negative regulation of protein-containing complex assembly; • negative regulation of DNA binding; • negative regulation of Wnt signaling pathway; • regulation of vascular permeability involved in acute inflammatory response; • GO:1901227 negative regulation of transcription by RNA polymerase II; • Đường truyền tín hiệu WNT; • negative regulation of protein binding; • negative regulation of DNA-binding transcription factor activity; • branching involved in ureteric bud morphogenesis; • positive regulation of osteoblast differentiation; • positive regulation of monocyte differentiation; • negative regulation of transcription initiation from RNA polymerase II promoter; • negative regulation of mesenchymal cell proliferation; • anterior/posterior pattern specification;
	Nguồn: Amigo / QuickGO
Gen cùng nguồn
	56998
	n/a
	ENSG00000178585
	n/a
	Q9NSA3
	n/a
	NM_020248; NM_001012329
	n/a
	NP_001012329; NP_064633
	n/a
	Wikidata
Xem/Sửa Người

Protein tương tác beta-catenin 1 (tiếng Anh: Beta-catenin-interacting protein 1) là protein ở người được mã hóa bởi gen CTNNBIP1.^[2]^[3]

Chức năng

Protein mã hóa bởi gen này liên kết với CTNNB1 và ngăn chặn tương tác giữa CTNNB1 và những thành viên thuộc họ TCF (yếu tố phiên mã tế bào T, T-cell transcription factor). Đây cũng là một yếu tố âm tính thuộc con đường tín hiệu Wnt.^[2]

Tham khảo

^ “Human PubMed Reference:”.
^ ^a ^b “Entrez Gene: catenin”.
^ Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T (tháng 7 năm 2000). “Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein”. Genes Dev. 14 (14): 1741–9. PMC 316784. PMID 10898789.

Đọc thêm

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