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Cychlorphine

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Cychlorphine
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC23H25ClN4O
Molar mass408.93 g·mol−1
3D model (JSmol)
  • CC(C1=CC=C(C=C1)Cl)N2CCC(CC2)N3C4=CC=CC=C4N(C3=O)CCC#N
  • InChI=1S/C23H25ClN4O/c1-17(18-7-9-19(24)10-8-18)26-15-11-20(12-16-26)28-22-6-3-2-5-21(22)27(23(28)29)14-4-13-25/h2-3,5-10,17,20H,4,11-12,14-16H2,1H3
  • Key:SWWAVNFEFVMDAG-UHFFFAOYSA-N

Cychlorphine (N-Propionitrile chlorphine) is synthetic opioid chemical compound which has been sold as a designer drug, reported in five European countries since 2024, and in the USA.[1] It has been found in Canada as of September 2025.[2] It is similar in chemical structure to known opioid agonists such as brorphine and spirochlorphine, and is claimed to be an opioid with similar or slightly higher potency than fentanyl, but no pharmacological data for cychlorphine has been published.[3][4][5] It is not a structural analog of morphine, despite the similar name.

At least 5 people have died from a cychlorphine overdose in England in 2025.[6] Furthermore, it has been detected as the sole active opioid in fake pharmaceutical opioid preparations that are supposed to contain hydromorphone or oxycodone, further increasing the risk of accidental overdoses.[2]

It added to the German NpSG in December 2025.[7]

See also

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References

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  1. ^ Sprague JE, Toms JA, Ratermann CF (December 2025). "Non-fatal opioid overdose associated predominantly with the benzimidazolone, cychlorphine". Clinical Toxicology. Philadelphia, Pa.: 1–2. doi:10.1080/15563650.2025.2594070. PMID 41347459.
  2. ^ a b Alevato J (November 4, 2025). "A new opioid has been found in Toronto's drug supply and users may not even know it". CBC.ca. Retrieved December 7, 2025.
  3. ^ "Chlorphine" (PDF). NPS Discovery — New Drug Monograph. The Center for Forensic Science Research & Education (CSFRE).
  4. ^ "European Drug Report 2025 – Full Book" (PDF). European Union Drugs Agency (euda.europa.eu). 6 June 2025.
  5. ^ US 3318900, Janssen PA, "Derivatives of benzimidazolinyl piperidine", issued 9 May 1967, assigned to Janssen Pharmaceutica NV 
  6. ^ Barradale G (December 5, 2025). "Warning over new opioid 200 times stronger than heroin as three dead within days". The Big Issue. Retrieved December 7, 2025.
  7. ^ "synthetisches Opioid Cychlorphine im Raum Karlsruhe". Drogenportal der Deutschen Aidshilfe (in German). 2025-12-17. Retrieved 2025-12-27.