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This is the talk page for discussing improvements to the MDMA article. This is not a forum for general discussion of the subject of the article.

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about MDMA. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC

Text and/or other creative content from this version of Effects of MDMA on the human body was copied or moved into MDMA with this edit on 17 October 2014. The former page's history now serves to provide attribution for that content in the latter page, and it must not be deleted as long as the latter page exists.

MDMA was a good article, but it was removed from the list as it no longer met the good article criteria at the time. There are suggestions below for improving the article. If you can improve it, please do; it may then be renominated. Review: May 26, 2006. (Reviewed version).

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Should we add that some users chew gum in order to deal with grinding teeth? Since the article is semi-protected, I wanted to check before just adding it in (especially since finding a good source for this is trickier than I though). Niplav (talk) 13:57, 7 February 2024 (UTC)[reply]

I have a proposition to add some text regarding Danny Leclère who developed in the 1990's a formula to produce "pure XTC" as party drug and set up a worldwide illegal network to have the drugs distributed. It's because if him XTC became popular in nightlife. The formula of Leclère is still the most used in the manufacturing of (illegal) XTC. Valid/Trusted references can be found in the article about Danny Leclère. I think a short topic in the article of MDMA is advisable due to Leclère his role in production/distribution of illegal XTC. Ino mart (talk) 15:31, 6 March 2024 (UTC)[reply]

is "pure XTC" MDMA? Bon courage (talk) 15:55, 6 March 2024 (UTC)[reply]

According the documentary "Bad, Bad Belgium" the term "pure XTC" refers to the formula by Leclère: it is the first XTC-formula which only contains MDMA as drug. At that time, MDMA-drugs also contained other ingredients such as meta-Chlorophenylpiperazine and para-Methoxy-N-methylamphetamine.

The section incorrectly reads "As of 2017, MDMA has no accepted medical indications.[where?] Before it was widely banned, it saw limited use in psychotherapy. In 2017 the United States Food and Drug Administration (FDA) approved limited research on MDMA-assisted psychotherapy for post-traumatic stress disorder (PTSD), with some preliminary evidence that MDMA may facilitate psychotherapy efficacy for PTSD.".

MDMA has been approved for the treatment of PTSD in Australia (https://www.tga.gov.au/news/media-releases/change-classification-psilocybin-and-mdma-enable-prescribing-authorised-psychiatrists). The accepted medical indication in this case is thus PTSD.

Additionally, the paragraph is very US-centric, in a way that does not fit Wikipedia.

Suggestion to edit the paragraph to: "In 2023, MDMA was approved for the treatment of PTSD in Australia[1]. As of June 2024, it is currently not approved for medical use in other countries." 158.174.187.29 (talk) 12:58, 8 June 2024 (UTC)[reply]

This edit request has been answered. Set the |answered= parameter to no to reactivate your request.

Add a “metabolism” section going more in depth about the bodies metabolism of the drug, like how it is metabolised by CYP2D6 into MDA through demethylation Big Mocc (talk) 22:09, 18 July 2024 (UTC)[reply]

 Not done: please provide reliable sources that support the change you want to be made. Left guide (talk) 23:47, 18 July 2024 (UTC)[reply]

https://pubmed.ncbi.nlm.nih.gov/15228154/

https://pubmed.ncbi.nlm.nih.gov/11599334/

https://www.euda.europa.eu/publications/drug-profiles/mdma_en

these cover metabolism by the enzyme i mentioned, and how most of the drug is excreted unchanged Big Mocc (talk) 13:38, 18 June 2025 (UTC)[reply]

"Use of MDMA individually or in small groups in a quiet environment and when concentrating, is associated with increased lucidity, concentration, sensitivity to aesthetic aspects of the environment, enhanced awareness of emotions, and improved capability of communication."

This is complete and utter BS.

"In our opinion, the most interesting and specific potentiality of MDMA is its capability, in certain situations, to "open the center of the heart" and therefore in the rest of this article this state will be mainly dealt with."

Its trash with three citations. Unscientific trash. Fix it, please. 2A02:2121:61B:75DD:790D:87CA:AC33:F03E (talk) 21:55, 10 October 2024 (UTC)[reply]

The first quote is not complete and utter BS if a significant number of subjects in a study of MDMA’s effects cited those effects mentioned. I can certainly attest that they were all on my own list of experiences on MDMA. The only thing I would disagree with is the need to be alone or in a small group. I watched the premiere of The Matrix in a crowded theater while taking my first dose of “E” as it was named by the friend who purchased the pill for me. Imagine our surprise when pills became a significant part of the story. We walked along the beach in San Francisco among a large number of others and noticed amazing natural patterns in the sand we’d never noticed before. We realized a generous enhancement of our ability to associate positively with everyday things, some which previously only held negative responses. One example was an overflowing trashcan. We agreed that it represented both the thoughtfulness of a society to provide the trashcan and the willingness by the public at large to responsibly use it, though it had not been emptied promptly. You could call it the “bright side effect” in that we were able to see the beauty in everything. 2601:647:8582:3950:5493:AC60:C7DE:9C86 (talk) 08:08, 29 October 2025 (UTC)[reply]