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Reference fix.

[edit]

The following references need to be fixed.

  • Reference number 3: [1]
  • Reference 4: [2]
  • Reference 5: [3]
  • Please change the line Refetoff is known for discovering resistance to thyroid hormone (RTH) to Refetoff discovered resistance to thyroid hormone. So that it aligns with NPOV.
  • Please remove this line to align with NPOV: His scholarly contributions include publications in journals such as Endocrine Reviews, The Journal of Clinical Endocrinology & Metabolism, Nature Genetics, and Journal of Clinical Investigation Thyroid

HRShami (talk) HRShami (talk) 07:24, 8 May 2025 (UTC)[reply]

 Not done: You can do a archivebot, if I understand correctly its just a minor error, it should be fixed, by a bot if not, please reply to me! Valorrr (lets chat) 16:28, 21 May 2025 (UTC)[reply]
Hello Valorrr. I tried using archivebot, but it does not work for fixing citation. Also, I have requested two other edits as well that cannot be done through a bot. HRShami (talk) 09:33, 26 May 2025 (UTC)[reply]
 Note: Marking for another editor. Valorrr (lets chat) 16:42, 26 May 2025 (UTC)[reply]

References

  1. ^ Sakurai, A.; Takeda, K.; Ain, K.; Ceccarelli, P.; Nakai, A.; Seino, S.; Bell, G. I.; Refetoff, S.; DeGroot, L. J. (November 1989). "Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta". Proceedings of the National Academy of Sciences of the United States of America. 86 (22): 8977–8981. doi:10.1073/pnas.86.22.8977. ISSN 0027-8424.
  2. ^ Sunthornthepvarakul, Thongkum; Gottschalk, Michael E.; Hayashi, Yoshitaka; Refetoff, Samuel (19 January 1995). "Resistance to Thyrotropin Caused by Mutations in the Thyrotropin-Receptor Gene". New England Journal of Medicine. 332 (3): 155–160. doi:10.1056/NEJM199501193320305. ISSN 0028-4793.
  3. ^ Dumitrescu, Alexandra M.; Liao, Xiao-Hui; Abdullah, Mohamed S. Y.; Lado-Abeal, Joaquin; Majed, Fathia Abdul; Moeller, Lars C.; Boran, Gerard; Schomburg, Lutz; Weiss, Roy E.; Refetoff, Samuel (November 2005). "Mutations in SECISBP2 result in abnormal thyroid hormone metabolism". Nature Genetics. 37 (11): 1247–1252. doi:10.1038/ng1654. ISSN 1061-4036.

Changing sources in research section to secondary.

[edit]

In due course, I have understood that as a paid editor I should refrain from using primary sources in the research section, which is one of the reasons for the tag at the top. Therefore, I have changed the resources with secondary resources in the research section in this edit request. I have also removed lines that were not supported by secondary sources in this section. Please change the current research section with the text below.

Refetoff has worked in endocrinology, with research interests in congenital and genetic defects affecting thyroid hormone synthesis, transport, and action. Together with DeWind and DeGroot, he characterized a familial syndrome linking deaf-mutism, stippled epiphyses, goiter, and elevated PBI.[1]

Refetoff identified mutations in proteins that transport thyroid hormone in blood, namely thyroxine-binding globulin (TBG)[2] and albumin, causing familial dysalbuminemic hyperthyroxinemia.[3] He identified mutations in the gene NKX2.1 that encodes TTF1, resulting in thyroid, brain and lung abnormalities.[4] His laboratory uncovered mutations of the SLC16A2 gene, encoding the thyroid hormone cell membrane transporter MCT8, which cause severe thyroid hormone deprivation in the brain, resulting in psychoneuromotor abnormalities formerly described by Allan, Herndon, and Dudley.[5] Along with A.M. Dumitrescu and others, he documented that mutations in the SECISBP2 gene disrupted selenoprotein synthesis, impairing thyroid hormone metabolism.[6] HRShami (talk) 04:56, 18 June 2025 (UTC)[reply]

 Done Likeanechointheforest (talk) 17:29, 27 June 2025 (UTC)[reply]

References

  1. ^ Gershengorn, M C; Weintraub, B D (1 September 1975). "Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of "inappropriate secretion of TSH"". Journal of Clinical Investigation. 56 (3): 633–642. doi:10.1172/JCI108133.
  2. ^ Parad, R B; Kramer, J; Strunk, R C; Rosen, F S; Davis, A E (September 1990). "Dysfunctional C1 inhibitor Ta: deletion of Lys-251 results in acquisition of an N-glycosylation site". Proceedings of the National Academy of Sciences. 87 (17): 6786–6790. doi:10.1073/pnas.87.17.6786.
  3. ^ Dieu, Xavier; Bouzamondo, Nathalie; Briet, Claire; Illouz, Frédéric; Moal, Valérie; Boux de Casson, Florence; Bouhours-Nouet, Natacha; Reynier, Pascal; Coutant, Régis; Rodien, Patrice; Mirebeau-Prunier, Delphine (3 July 2020). "Familial Dysalbuminemic Hyperthyroxinemia: An Underdiagnosed Entity". Journal of Clinical Medicine. 9 (7): 2105. doi:10.3390/jcm9072105.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ Nettore, Immacolata Cristina; Mirra, Paola; Ferrara, Alfonso Massimiliano; Sibilio, Annarita; Pagliara, Valentina; Kay, Claudia Suemi Kamoi; Lorenzoni, Paulo Josè; Werneck, Lineu Cesar; Bruck, Isac; dos Santos, Lucia Helena Coutinho; Beguinot, Francesco; Salvatore, Domenico; Ungaro, Paola; Fenzi, Gianfranco; Scola, Rosana Herminia; Macchia, Paolo Emidio (June 2013). "Identification and Functional Characterization of a Novel Mutation in the NKX2-1 Gene: Comparison with the Data in the Literature". Thyroid. 23 (6): 675–682. doi:10.1089/thy.2012.0267.
  5. ^ Lin, Peng; Liu, Huituan; Lou, Jiwu; Lyu, Guizhen; Li, Yanwei; He, Peiqing; Fu, Youqing; Zhang, Ronghua; Zhang, Yuqiong; Yan, Tizhen (23 April 2025). "Novel SLC16A2 Frameshift Mutation as a Cause of Allan-Herndon-Dudley Syndrome and its Implications for Carrier Screening". Pharmacogenomics and Personalized Medicine. 18: 85–94. doi:10.2147/PGPM.S492647.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Schoenmakers, Erik; Chatterjee, Krishna (1 September 2020). "Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency". Antioxidants & Redox Signaling. 33 (7): 481–497. doi:10.1089/ars.2020.8097.

Updating Awards

[edit]

In order to align with NPOV and verifiability, I have removed minor awards and awards that could not be verified from the awarding body's website. Please change the current list of awards with the list below.

HRShami (talk) 05:09, 18 June 2025 (UTC)[reply]

 Done Likeanechointheforest (talk) 17:27, 27 June 2025 (UTC)[reply]

References

  1. ^ "Paul Starr Award Lecture". American Thyroid Association. Retrieved 2025-06-18.
  2. ^ "Sidney H. Ingbar Distinguished Lectureship Award". American Thyroid Association. Retrieved 2025-04-23.
  3. ^ "Accolades go to faculty, clinical staff in biological sciences". UChicago News. Retrieved 2025-04-23.
  4. ^ "John B. Stanbury Thyroid Pathophysiology Medal". American Thyroid Association. Retrieved 2025-06-18.
  5. ^ "THE ENDOCRINE SOCIETY 2012 LAUREATE AWARDS". Molecular Endocrinology. 26 (8): 1468–1480. 1 August 2012. doi:10.1210/mend.26.8.zmg1468. ISSN 0888-8809.
  6. ^ "Honorary Members – European Thyroid Association". European Thyroid Association. Retrieved 2025-04-23.
  7. ^ "ETA prize winners 2019". European Thyroid Association. Retrieved 2025-04-23.

Updating lead section

[edit]

In this edit request, I am removing some extra information from the lead section. I am also removing primary sources and replacing it with a secondary source.

Samuel Refetoff is a Bulgarian-American endocrinologist and an academic. He is the Frederick H. Rawson Professor in Medicine and director of the Endocrinology Laboratories at The University of Chicago.[1]

Refetoff is known for discovering resistance to thyroid hormone (RTH), also known as Refetoff syndrome and its genetic and molecular basis, along with resistance to thyrotropin (RTSH) and a hereditary thyroid hormone metabolism defect caused by SECISBP2 gene mutations.[2]

Refetoff has received awards, including the Rosalind Pitt-Rivers Award from the British Thyroid Foundation,[3] the Stanbury Pathophysiology Medal from the American Thyroid Association,[4] and the Fred Conrad Koch Medal from the Endocrine Society.[5] HRShami (talk) 05:22, 30 June 2025 (UTC)[reply]

 Done Likeanechointheforest (talk) 15:53, 30 June 2025 (UTC)[reply]

References

  1. ^ "SAMUEL REFETOFF, MD Interview conducted by Michael Chappelle" (PDF). endocrine.org. Retrieved 2025-04-23.
  2. ^ Bianco, Antonio (May 2025). "Fifty Years of Support From the NIDDK for a Pioneer in Thyroid Research". Endocrinology,. 166 (5). doi:10.1210/endocr/bqaf060. Retrieved 30 June 2025.{{cite journal}}: CS1 maint: extra punctuation (link)
  3. ^ "The Pitt-Rivers and George Murray lectures". British Thyroid Association. Retrieved 2025-04-23.
  4. ^ "John B. Stanbury Thyroid Pathophysiology Medal". American Thyroid Association. Retrieved 2025-04-23.
  5. ^ "Past Laureate Award Recipients". Endocrine Society. 28 September 2022. Retrieved 2025-04-23.
[edit]

Hi Justlettersandnumbers. I have significantly edited the article since the paid editing tag was placed. Here are the major edits: removed primary sources from the research section, removed minor or non-verifiable awards, removed run of the mill information, edited text so that it aligns with NPOV. If you believe the issues that led to the paid editing tag have been addressed, would it be appropriate to remove the tag now? HRShami (talk) 04:21, 1 July 2025 (UTC)[reply]

HRShami, thanks for what you've done so far. The page still has a number of problems common to paid content, most glaringly the excessive use of capitals to make unimportant things seem more important. What it really needs is a full overhaul by an independent editor; I've added a copy edit tag in the hope of achieving that. Justlettersandnumbers (talk) 09:06, 1 July 2025 (UTC)[reply]

Addressing issue of excessive capitalization

[edit]

Based on the concern raised by another editor of excessive capitalization, I have removed capitalization where not needed in this edit request. Absolutely no change has been made in the content of the article.

Samuel Refetoff is a Bulgarian-American endocrinologist and an academic. He is the Frederick H. Rawson Professor in Medicine and director of the Endocrinology Laboratories at The University of Chicago.[1]

Refetoff is known for discovering resistance to thyroid hormone (RTH), also known as Refetoff Syndrome, and its genetic and molecular basis, along with resistance to thyrotropin (RTSH) and a hereditary thyroid hormone metabolism defect caused by SECISBP2 gene mutations.[2]

Education

[edit]

Refetoff completed his baccalaureate at the Lycée in Antwerp in 1955. He earned his B.Sc. (Hon.) in Biochemistry, from the University of Montreal in 1959 and obtained his M.D., C.M. from McGill University in 1963. During his postdoctoral training, he completed an internship at Notre Dame Hospital from 1964 to 1965, followed by residencies in internal medicine at the Good Samaritan Hospital (Los Angeles) from 1964 to 1965 and at the Lahey Clinic, Boston, Massachusetts, from 1965 to 1966.[3]

Refetoff trained in Endocrinology as an assistant in medicine at Peter Bent Brigham Hospital and as a research fellow in medicine at Harvard Medical School from 1966 to 1968.[4]

Career

[edit]

At the University of Chicago, Refetoff held appointments including director of the Thyroid Function Laboratory from 1973 to 1994. In 1977, he also assumed the position of professor of medicine, which he held until 2000, and since 2001, he has held the title of The Frederick H. Rawson Professor in Medicine. Since 1983, he has also been a professor of pediatrics and, since 2001, a member of the Committee on Genetics there. Additionally, he served as director of the Endocrinology Training Program during two separate periods, from 1978 to 1983 and from 1999 to 2004. He has been the director of the Endocrinology Laboratories since 1994.[5] He was the head of the Thyroid Study Unit from 2005 to 2022 and visited the Medical University of Sofia as a Fulbright senior specialist in 2011.[6]

Research

[edit]

Refetoff has worked in endocrinology, with research interests in congenital and genetic defects affecting thyroid hormone synthesis, transport, and action. Together with DeWind and DeGroot, he characterized a familial syndrome linking deaf-mutism, stippled epiphyses, goiter, and elevated PBI.[7]

Refetoff identified mutations in proteins that transport thyroid hormone in blood, namely thyroxine-binding globulin (TBG)[8] and albumin, causing familial dysalbuminemic hyperthyroxinemia.[9] He identified mutations in the gene NKX2.1 that encodes TTF1, resulting in thyroid, brain and lung abnormalities.[10] His laboratory uncovered mutations of the SLC16A2 gene, encoding the thyroid hormone cell membrane transporter MCT8, which cause severe thyroid hormone deprivation in the brain, resulting in psychoneuromotor abnormalities formerly described by Allan, Herndon, and Dudley.[11] Along with A.M. Dumitrescu and others, he documented that mutations in the SECISBP2 gene disrupted selenoprotein synthesis, impairing thyroid hormone metabolism.[12]

Awards and honors

[edit]

HRShami (talk) 04:33, 7 July 2025 (UTC) HRShami (talk) 04:33, 7 July 2025 (UTC)[reply]

References

  1. ^ "SAMUEL REFETOFF, MD Interview conducted by Michael Chappelle" (PDF). endocrine.org. Retrieved 2025-04-23.
  2. ^ Bianco, Antonio (May 2025). "Fifty Years of Support From the NIDDK for a Pioneer in Thyroid Research". Endocrinology. 166 (5). doi:10.1210/endocr/bqaf060. Retrieved 30 June 2025.
  3. ^ "SAMUEL REFETOFF, MD Interview conducted by Michael Chappelle" (PDF). endocrine.org. Retrieved 2025-04-23.
  4. ^ "Samuel Refetoff". Life in the Fast Lane (LITFL). 11 April 2019. Retrieved 2025-04-23.
  5. ^ "Samuel Refetoff" (PDF). Scientific Atlas. Retrieved 2025-04-23.
  6. ^ "Final Nominations for Bulgarian Fulbright Grantees in AY 2012-2013" (PDF). Bulgarian-American Fulbright Commission. Retrieved 2025-04-23.
  7. ^ Gershengorn, M C; Weintraub, B D (1 September 1975). "Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of "inappropriate secretion of TSH"". Journal of Clinical Investigation. 56 (3): 633–642. doi:10.1172/JCI108133. PMC 301911. PMID 1159077.
  8. ^ Parad, R B; Kramer, J; Strunk, R C; Rosen, F S; Davis, A E (September 1990). "Dysfunctional C1 inhibitor Ta: deletion of Lys-251 results in acquisition of an N-glycosylation site". Proceedings of the National Academy of Sciences. 87 (17): 6786–6790. Bibcode:1990PNAS...87.6786P. doi:10.1073/pnas.87.17.6786. PMC 54622. PMID 2118657.
  9. ^ Dieu, Xavier; Bouzamondo, Nathalie; Briet, Claire; Illouz, Frédéric; Moal, Valérie; Boux de Casson, Florence; Bouhours-Nouet, Natacha; Reynier, Pascal; Coutant, Régis; Rodien, Patrice; Mirebeau-Prunier, Delphine (3 July 2020). "Familial Dysalbuminemic Hyperthyroxinemia: An Underdiagnosed Entity". Journal of Clinical Medicine. 9 (7): 2105. doi:10.3390/jcm9072105. PMC 7408830. PMID 32635414.
  10. ^ Nettore, Immacolata Cristina; Mirra, Paola; Ferrara, Alfonso Massimiliano; Sibilio, Annarita; Pagliara, Valentina; Kay, Claudia Suemi Kamoi; Lorenzoni, Paulo Josè; Werneck, Lineu Cesar; Bruck, Isac; dos Santos, Lucia Helena Coutinho; Beguinot, Francesco; Salvatore, Domenico; Ungaro, Paola; Fenzi, Gianfranco; Scola, Rosana Herminia; Macchia, Paolo Emidio (June 2013). "Identification and Functional Characterization of a Novel Mutation in the NKX2-1 Gene: Comparison with the Data in the Literature". Thyroid. 23 (6): 675–682. doi:10.1089/thy.2012.0267. PMID 23379327.
  11. ^ Lin, Peng; Liu, Huituan; Lou, Jiwu; Lyu, Guizhen; Li, Yanwei; He, Peiqing; Fu, Youqing; Zhang, Ronghua; Zhang, Yuqiong; Yan, Tizhen (23 April 2025). "Novel SLC16A2 Frameshift Mutation as a Cause of Allan-Herndon-Dudley Syndrome and its Implications for Carrier Screening". Pharmacogenomics and Personalized Medicine. 18: 85–94. doi:10.2147/PGPM.S492647. PMC 12034286. PMID 40291819.
  12. ^ Schoenmakers, Erik; Chatterjee, Krishna (1 September 2020). "Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency". Antioxidants & Redox Signaling. 33 (7): 481–497. doi:10.1089/ars.2020.8097. PMC 7409586. PMID 32295391.
  13. ^ "Paul Starr Award Lecture". American Thyroid Association. Retrieved 2025-06-18.
  14. ^ "Sidney H. Ingbar Distinguished Lectureship Award". American Thyroid Association. Retrieved 2025-04-23.
  15. ^ "Accolades go to faculty, clinical staff in biological sciences". UChicago News. Retrieved 2025-04-23.
  16. ^ "John B. Stanbury Thyroid Pathophysiology Medal". American Thyroid Association. Retrieved 2025-06-18.
  17. ^ "The Endocrine Society 2012 Laureate Awards". Molecular Endocrinology. 26 (8): 1468–1480. 1 August 2012. doi:10.1210/mend.26.8.zmg1468. ISSN 0888-8809. PMC 5416988.
  18. ^ "Honorary Members – European Thyroid Association". European Thyroid Association. Retrieved 2025-04-23.
  19. ^ "ETA prize winners 2019". European Thyroid Association. Retrieved 2025-04-23.
 Done Encoded  Talk 💬 13:49, 7 July 2025 (UTC)[reply]

Restoration of paid contributions template

[edit]

I restored the

tag because there are indications of paid editing on this article that have not been fully disclosed or addressed.

Per Wikipedia’s Terms of Use and COI guidelines, this tag should remain until transparency and neutrality are confirmed. 116.58.66.116 (talk) 11:08, 20 August 2025 (UTC)[reply]