Recettore della somatostatina 3
| Recettore della somatostatina 3 | |
|---|---|
| Gene | |
| HUGO | SSTR3 |
| Entrez | 6753 |
| Locus | Chr. 22 q13.1 |
| Proteina | |
| OMIM | 182453 |
| UniProt | P32745 |
Il recettore della somatostatina 3 è una proteina recettoriale codificata nell'uomo dal gene SSTR3[1][2].
La somatostatina agisce in molti siti recettoriali inibendo il rilascio di ormoni e altre proteine secretorie. Gli effetti biologici sono probabilmente mediati da una famiglia di recettori accoppiati a proteine G espressi in modalità tessuto-specifiche. In particolare SSTR3 fa parte della superfamiglia dei recettori con sette domini transmembrana ed è iperespresso a livello del cervello e delle insulae pancreatiche. Il recettore è associato funzionalmente con un'adenilato ciclasi[2].
Note
[modifica | modifica wikitesto]- ^ Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI, Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms, in Genomics, vol. 15, n. 2, aprile 1993, pp. 449–452, DOI:10.1006/geno.1993.1088, PMID 8449518.
- ^ a b Entrez Gene: SSTR3 somatostatin receptor 3, su ncbi.nlm.nih.gov.
Bibliografia
[modifica | modifica wikitesto]- Yamada Y, Reisine T, Law SF, Y Ihara, A Kubota, S Kagimoto, M Seino, Y Seino e GI Bell, Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase, in Mol. Endocrinol., vol. 6, n. 12, 1993, pp. 2136–2142, DOI:10.1210/me.6.12.2136, PMID 1337145.
- Yamada Y, Post SR, Wang K, HS Tager, GI Bell e S Seino, Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney, in Proc. Natl. Acad. Sci. U.S.A., vol. 89, n. 1, 1992, pp. 251–255, DOI:10.1073/pnas.89.1.251, PMC 48214, PMID 1346068.
- Corness JD, Demchyshyn LL, Seeman P, H Vantol, C Srikant, G Kent, Y Patel e H Niznik, A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides, in FEBS Lett., vol. 321, 2–3, 1993, pp. 279–284, DOI:10.1016/0014-5793(93)80124-D, PMID 8097479.
- Law SF, Zaina S, Sweet R, K Yasuda, GI Bell, J Stadel e T Reisine, Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation, in Mol. Pharmacol., vol. 45, n. 4, 1994, pp. 587–90, PMID 8183236.
- Kaupmann K, Bruns C, Hoyer D, Klaus Seuwen e Hermann Lübbert, Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain, in FEBS Lett., vol. 331, 1–2, 1993, pp. 53–59, DOI:10.1016/0014-5793(93)80296-7, PMID 8405411.
- Sharma K, Patel YC, Srikant CB, Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3, in Mol. Endocrinol., vol. 10, n. 12, 1997, pp. 1688–1696, DOI:10.1210/me.10.12.1688, PMID 8961277.
- Fukusumi S, Kitada C, Takekawa S, H Kizawa, J Sakamoto, M Miyamoto, S Hinuma, K Kitano e M Fujino, Identification and characterization of a novel human cortistatin-like peptide, in Biochem. Biophys. Res. Commun., vol. 232, n. 1, 1997, pp. 157–163, DOI:10.1006/bbrc.1997.6252, PMID 9125122.
- Ain KB, Taylor KD, Tofiq S, Venkataraman G, Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines, in J. Clin. Endocrinol. Metab., vol. 82, n. 6, 1997, pp. 1857–1862, DOI:10.1210/jc.82.6.1857, PMID 9177396.
- de Lecea L, Ruiz-Lozano P, Danielson PE, J Peellekirley, P Foye, W Frankel e J Sutcliffe, Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin, in Genomics, vol. 42, n. 3, 1997, pp. 499–506, DOI:10.1006/geno.1997.4763, PMID 9205124.
- Roth A, Kreienkamp HJ, Meyerhof W, Richter D, Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization, in J. Biol. Chem., vol. 272, n. 38, 1997, pp. 23769–23774, DOI:10.1074/jbc.272.38.23769, PMID 9295322.
- Dunham I, Shimizu N, Roe BA, R. Bruskiewich, D. M. Beare, M. Clamp, L. J. Smink, R. Ainscough e J. P. Almeida, The DNA sequence of human chromosome 22, in Nature, vol. 402, n. 6761, 1999, pp. 489–495, DOI:10.1038/990031, PMID 10591208.
- Zatelli MC, Tagliati F, Taylor JE, R Rossi, MD Culler e EC Degli Uberti, Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt, in J. Clin. Endocrinol. Metab., vol. 86, n. 5, 2001, pp. 2161–2169, DOI:10.1210/jc.86.5.2161, PMID 11344221.
- Talme T, Ivanoff J, Hägglund M, R. J. J. Van Neerven, A. Ivanoff e K. G. Sundqvist, Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3, in Clin. Exp. Immunol., vol. 125, n. 1, 2001, pp. 71–79, DOI:10.1046/j.1365-2249.2001.01577.x, PMC 1906108, PMID 11472428.
- Pasquali D, Notaro A, Esposito D, P Vassallo, G Bonavolontà, A Bellastella e AA Sinisi, [Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy], in Minerva Endocrinol., vol. 26, n. 3, 2002, pp. 175–9, PMID 11753241.
- Papotti M, Bongiovanni M, Volante M, Allìa e., Landolfi s., Helboe l., Schindler m., Cole s. e Bussolati g., Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis, in Virchows Arch., vol. 440, n. 5, 2002, pp. 461–475, DOI:10.1007/s00428-002-0609-x, PMID 12021920.
- Ferone D, Pivonello R, Van Hagen PM, VA Dalm, EG Lichtenauer-Kaligis, M Waaijers, PM Van Koetsveld, DM Mooy e A Colao, Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes, in Am. J. Physiol. Endocrinol. Metab., vol. 283, n. 5, 2002, pp. E1056–66, DOI:10.1152/ajpendo.00205.2001, PMID 12376335.
- Pasquali D, Notaro A, Bonavolonta' G, P Vassallo, A Bellastella e AA Sinisi, Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease, in J. Clin. Endocrinol. Metab., vol. 87, n. 11, 2002, pp. 5125–5129, DOI:10.1210/jc.2002-020790, PMID 12414882.
- Dizeyi N, Konrad L, Bjartell A, H Wu, V Gadaleanu, J Hansson, L Helboe e P Abrahamsson, Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines, in Urol. Oncol., vol. 7, n. 3, 2002, pp. 91–98, DOI:10.1016/S1078-1439(01)00173-9, PMID 12474541.
- Strausberg RL, Feingold EA, Grouse LH, JG Derge, RD Klausner, FS Collins, L Wagner, CM Shenmen e GD Schuler, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences, in Proc. Natl. Acad. Sci. U.S.A., vol. 99, n. 26, 2003, pp. 16899–16903, DOI:10.1073/pnas.242603899, PMC 139241, PMID 12477932.
Voci correlate
[modifica | modifica wikitesto]Collegamenti esterni
[modifica | modifica wikitesto]- Recettore della somatostatina: sst3, su IUPHAR Database of Receptors and Ion Channels, International Union of Basic and Clinical Pharmacology (archiviato dall'url originale il 18 settembre 2012).
- Mesh, su nlm.nih.gov.
