6-Tioinozinska kiselina

6-Tioinozinska kiselina
	[(2R,3S,4R,5R)-3,4-Dihidroksi-5-(6-sulfaniliden-3H-purin-9-il)oksolan-2-il]metil dihidrogen fosfat
Identifikacija
CAS registarski broj	53-83-8
PubChem	3034391
Jmol-3D slike	Slika 1
SMILES
	O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2NC=NC3=S)O[C@@H]1COP(O)(O)=O
InChI
	InChI=1S/C10H13N4O7PS/c15-6-4(1-20-22(17,18)19)21-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)23/h2-4,6-7,10,15-16H,1H2,(H,11,12,23)(H2,17,18,19)/t4-,6-,7-,10-/m1/s1 ; Kod: ZKRFOXLVOKTUTA-KQYNXXCUSA-N
Svojstva
Molekulska formula	C10H13N4O7PS
Molarna masa	364.27 g/mol
	; ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Tioinozinska kiselina je intermedijar u metabolizmu azatioprina.^[3] Azatioprin^[4] je imunosupresivni lek koji se koadministrira sa ciclosporinom i kortikosteroidima da bi se sprečilo neprihvatanje transplantacije organa^[5]. Azatioprin, prolek 6-mercaptopurina (6-MP), dejstvuje kao antimetabolit purina nakon intracelularne konverzije hipoksantinguanin fosforibosil transferazom u 6-tioinosine monofosfat (6-TIMP).

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ L Fletcher and J L Maddocks (1980). „Assay of thioinosinic acid, an active metabolite of azathioprine, in human lymphocytes.”. Br J Clin Pharmacol. 10 (3): 287–292.
↑ Thomas L. Lemke, David A. Williams, ur. (2002). Foye's Principles of Medicinal Chemistry (5 izd.). Baltimore: Lippincott Willams & Wilkins. str. 785-6. ISBN 0-7817-4443-1.
↑ Simmonds RL, Canafax DM, Fryd SD, Asher NL, Payne WD, Sutherland DER, Narajan JS (1986). „New immunosuppressive drug combination for mismatched related and cadaveric renal transplantation”. Transplant Proc 18: 76–81.

Portal Hemija