ATC-0175
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| (IUPAC) ime
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| N-[cis-4-([4-(dimetilamino)hinazolin-2-il]amino)cikloheksil]-3,4-difluorobenzamid
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| Klinički podaci
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| Identifikatori
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| ATC kod
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?
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| ChemSpider[1]
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8109661
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| Hemijski podaci
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| Formula
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C23H25F2N5O
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| Mol. masa
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425,473
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| SMILES
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eMolekuli & PubHem
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| InChI |
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InChI=1S/C23H25F2N5O/c1-30(2)21-17-5-3-4-6-20(17)28-23(29-21)27-16-10-8-15(9-11-16)26-22(31)14-7-12-18(24)19(25)13-14/h3-7,12-13,15-16H,8-11H2,1-2H3,(H,26,31)(H,27,28,29)  Y
Key: FAIMGWSOSCFGRU-UHFFFAOYSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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ATC-0175 je lek koji se koristi u naučnim istraživanjima. On je selektivni nepeptidni antagonist melanin-koncentrirajućeg hormonskog receptora MCH1. U životinjskim studijama je pokazano da proizvodi anksiolitičke i antidepresivne efekte, bez sedativnih ili ataksičnih nuspojava.[2][3][4]
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Chaki S, Funakoshi T, Hirota-Okuno S, Nishiguchi M, Shimazaki T, Iijima M, Grottick AJ, Kanuma K, Omodera K, Sekiguchi Y, Okuyama S, Tran TA, Semple G, Thomsen W (May 2005). „Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists”. The Journal of Pharmacology and Experimental Therapeutics 313 (2): 831–9. DOI:10.1124/jpet.104.081711. PMID 15677346.
- ↑ Kanuma K, Omodera K, Nishiguchi M, Funakoshi T, Chaki S, Semple G, Tran TA, Kramer B, Hsu D, Casper M, Thomsen B, Sekiguchi Y (September 2005). „Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1”. Bioorganic & Medicinal Chemistry Letters 15 (17): 3853–6. DOI:10.1016/j.bmcl.2005.05.121. PMID 16002290.
- ↑ Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y (2005). „ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety”. CNS Drug Reviews 11 (4): 341–52. DOI:10.1111/j.1527-3458.2005.tb00052.x. PMID 16614734.
Šablon:Neuropeptidni ligandi
