Bradikininski receptor B1

Bradikininski receptor B1
Identifikatori
Simboli	BDKRB1; B1BKR; B1R; BKB1R; BKR1; BRADYB1
Vanjski ID	OMIM: 600337 MGI: 88144 HomoloGene: 570 IUPHAR: B1 GeneCards: BDKRB1 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost bradikininskog receptora;
Celularna komponenta	• endoplazmatični retikulum; • ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• inflamatorni respons; • prenos signala; • signalni put G-protein spregnutog receptora; • elevacija koncentracije citosolnih jona kalcijuma;
Pregled RNK izražavanja
	podaci
Ortolozi

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Bradikininski receptor B1 (B₁) je G-protein spregnuti receptor kodiran BDKRB1 genom kod ljudi. Njegov principalni ligand je bradikinin, peptid sa 9 aminokiselina koji se formira u patofiziološkim uslovima kao što je inflamacija, trauma, opekotine, šok, i alergija. B₁ receptor je jedan od dva G protein-spregnuta receptora za koje je utvrđeno da vezuju bradikinin i posreduju response na te patofiziološke uslove.

B₁ protein se sintetiše de novo nakon povrede tkiva. Njegovo vezivanje za receptor dovodi do povećanja citosolne koncentracije jona kalcijuma, što ultimatno dovodi do hroničnog i akutnog inflamatornog responsa.^[1]

Reference

↑ „Entrez Gene: BDKRB1 bradykinin receptor B1”.

Literatura

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Leeb T, Mathis SA, Leeb-Lundberg LM (1997). „The sixth transmembrane domains of the human B1 and B2 bradykinin receptors are structurally compatible and involved in discriminating between subtype-selective agonists.”. J. Biol. Chem. 272 (1): 311–7. DOI:10.1074/jbc.272.1.311. PMID 8995263.
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Ignjatovic T, Tan F, Brovkovych V, et al. (2002). „Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.”. J. Biol. Chem. 277 (19): 16847–52. DOI:10.1074/jbc.M200355200. PMID 11880373.
Newton R, Eddleston J, Haddad el-B, et al. (2002). „Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone.”. Eur. J. Pharmacol. 441 (3): 193–202. DOI:10.1016/S0014-2999(01)01624-7. PMID 12063092.
Kang DS, Leeb-Lundberg LM (2002). „Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G(q/11)-mediated [correction of G(9/11)-mediated] phospholipase Cbeta activity.”. Mol. Pharmacol. 62 (2): 281–8. DOI:10.1124/mol.62.2.281. PMID 12130679.
Christiansen SC, Eddleston J, Woessner KM, et al. (2002). „Up-regulation of functional kinin B1 receptors in allergic airway inflammation.”. J. Immunol. 169 (4): 2054–60. PMID 12165532.
Lamb ME, Zhang C, Shea T, et al. (2003). „Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells.”. Biochemistry 41 (48): 14340–7. DOI:10.1021/bi020231d. PMID 12450400.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kang DS, Ryberg K, Mörgelin M, Leeb-Lundberg LM (2004). „Spontaneous formation of a proteolytic B1 and B2 bradykinin receptor complex with enhanced signaling capacity.”. J. Biol. Chem. 279 (21): 22102–7. DOI:10.1074/jbc.M402572200. PMID 15033977.
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Povezano

Bradikininski receptor

Spoljašnje veze

„Bradykinin Receptors: B₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

[entrez-1] „Entrez Gene: BDKRB1 bradykinin receptor B1”.

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