Cefotiam

Cefotiam
(IUPAC) ime
(6R,7R)-7-[2-(2-amino-1,3-tiazol-4-il)acetamido]-3-[({1-[2-(dimetilamino)etil]-1H-1,2,3,4-tetrazol-5-il}sulfanil)metil]-8-okso-5-tia-1-azabiciklo[4.2.0]okt-2-en-2-karboksilna kiselina
Klinički podaci
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 61622-34-2
ATC kod J01DC07
PubChem[1][2] 43708
DrugBank DB00229
ChemSpider[3] 39831
ChEMBL[4] CHEMBL355510 DaY
Hemijski podaci
Formula C18H23N9O4S3 
Mol. masa 525.628
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Poluvreme eliminacije 1 sat
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Cevalotiam' je jedan od cefalosporina, koji ima širok spektar dejstva proti gram-pozitivnih i gram-negativnih mikroorganizama.[5][6][7][8][9]

Reference

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  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Muller R, Bottger C, Wichmann G: Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients. Arzneimittelforschung. 2003;53(2):126-32. PMID 12642969
  6. Kolben M, Mandoki E, Ulm K, Freitag K: Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section. Eur J Clin Microbiol Infect Dis. 2001 Jan;20(1):40-2. PMID 11245321
  7. Shimizu S, Chen KR, Miyakawa S: Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses. Dermatology. 1996;192(2):174-6. PMID 8829507
  8. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682. 
  9. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412. 

Vanjske veze

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