GPR34

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G protein-spregnuti receptor 34
Identifikatori
Simboli	GPR34;
Vanjski ID	OMIM: 300241 MGI: 1346334 HomoloGene: 36174 IUPHAR: GPR34 GeneCards: GPR34 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu sličnog receptora • receptorska aktivnost • aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog Celularna komponenta • integralno sa ćelijskom membranom • membrana Biološki proces • prenos signala • signalni put G-protein spregnutog receptora
Ortolozi
Vrsta	Čovek	Miš
Entrez	2857	23890
Ensembl	ENSG00000171659	ENSMUSG00000040229
UniProt	Q9UPC5	Q3USC5
RefSeq (mRNA)	NM_001033513	NM_011823
RefSeq (protein)	NP_001028685	NP_035953
Lokacija (UCSC)	Chr X: 41.43 - 41.44 Mb	Chr X: 12.79 - 12.8 Mb
PubMed pretraga	[1]	[2]

GPR34, G protein-spregnuti receptor 34, je protein koji je kod čoveka kodiran GPR34 genom.^[1][2][3]

G protein-spregnuti receptori, kao što je GPR34, su integralni membranski proteini koji sadrže 7 transmembranskih domaina (TM). Ti proteini prenose signale u unutrašnjost ćelije putem aktivacije heterotrimernih G proteina koji zatim aktiviraju razne efektorske proteine, što ultimatno dovodi do fiziološkog responsa.^[3]

Literatura

1. Schoneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (Aug 1999). „A novel subgroup of class I G-protein-coupled receptors”. Biochim Biophys Acta 1446 (1-2): 57–70. PMID 10395919. 
2. Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). „Discovery of three novel orphan G-protein-coupled receptors”. Genomics 56 (1): 12–21. DOI:10.1006/geno.1998.5655. PMID 10036181. 
3. „Entrez Gene: GPR34 G protein-coupled receptor 34”. 

Dodatna literatura

• Hillier LD, Lennon G, Becker M, et al. (1997). „Generation and analysis of 280,000 human expressed sequence tags.”. Genome Res. 6 (9): 807–28. DOI:10.1101/gr.6.9.807. PMID 8889549. 
• Jacobi FK, Broghammer M, Pesch K, et al. (2000). „Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1.”. Hum. Genet. 107 (1): 89–91. DOI:10.1007/s004390050017. PMID 10982042. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Otsuki T, Ota T, Nishikawa T, et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”. DNA Res. 12 (2): 117–26. DOI:10.1093/dnares/12.2.117. PMID 16303743. 
• Engemaier E, Römpler H, Schöneberg T, Schulz A (2006). „Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34.”. Genomics 87 (2): 254–64. DOI:10.1016/j.ygeno.2005.10.001. PMID 16338117. 
• Oh JH, Yang JO, Hahn Y, et al. (2006). „Transcriptome analysis of human gastric cancer.”. Mamm. Genome 16 (12): 942–54. DOI:10.1007/s00335-005-0075-2. PMID 16341674.