Karboksipeptidaza B

Karboksipeptidaza B
Identifikatori
EC broj	3.4.17.2
CAS broj	9025-24-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Karboksipeptidaza B (EC 3.4.17.2, protaminaza, pankreasna karboksipeptidaza B, tkivna karboksipeptidaza B, peptidil-L-lizin (L-arginin) hidrolaza) je enzim.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferentno odvajanje C-terminalne aminokiseline lizina ili arginina.

Ovaj cinkov enzim se formira iz prokarboksipeptidaze B.

Reference

1. Folk, J.E. (1970). „Carboxypeptidase B (porcine pancreas)”. Methods Enzymol. 19: 504-508. 
2. Brodrick, J.W., Geokas, M.C. and Largman, C. (1976). „Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion”. Biochim. Biophys. Acta 452: 468-481. PMID 1009123. 
3. Butterworth, J. and Duncan, J.J. (1979). „Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis”. Clin. Chim. Acta 97: 39-43. PMID 40714. 
4. Wallace, E.F., Evans, C.J., Jurik, S.M., Mefford, I.N. and Barchas, J.D. (1982). „Carboxypeptidase B activity from adrenal medulla. Is it involved in the processing of proenkephalin?”. Life Sci. 31: 1793-1796. PMID 6130442. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Carboxypeptidase+B