Karboksipeptidaza E (EC 3.4.17.10, karboksipeptidaza H, enkefalinska konvertaza, kobaltom stimulisana hromafin granularna karboksipeptidaza, enkefalinska konvertaza, membranska karboksipeptidaza, enkefalinska prekursorska endopeptidaza, enkefalinska prekursorska karboksipeptidaza, peptidilna-L-lizin(-L-arginin) hidrolaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje C-terminalnog arginina ili lizina sa polipeptida
Ovaj cinkov enzim aktivira jon Co2+.
- ↑ Qian, Y.M., Varlamov, O. and Fricker, L.D. (1999). „Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway”. J. Biol. Chem. 274: 11582-11586. PMID 10206965.
- ↑ Fricker, L.D. (1998). „Carboxypeptidase E/H”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 1341-1344.
- ↑ Fricker, L.D. (1995). „Methods for studying carboxypeptidase E”. Methods Neurosci. 23: 237-250.
- ↑ Manser, E., Fernandez, D. (1990). „, Loo,L., Goh, P.Y., Monfries, C., Hall, C. and Lim, L. Human carboxypeptidase E: isolation and characterisaton of the cDNA, sequence conservation, expression and processing in vitro”. Biochem. J. 267: 517-525. PMID 2334405.
- ↑ Fricker, L.D. (1988). „Carboxypeptidase E”. Annu. Rev. Physiol. 50: 309-321. PMID 2897826.
- Fricker, L.D. (1998). „Carboxypeptidase E/H”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 1341-1344.