LPHN3

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Latrofilin 3
Identifikatori
Simboli	LPHN3; CIRL3; LEC3
Vanjski ID	MGI: 2441950 HomoloGene: 22878 IUPHAR: LPHN3 GeneCards: LPHN3 Gene
Ontologija gena Molekularna funkcija • aktivnost G protein spregnutog receptora Celularna komponenta • integralno sa ćelijskom membranom • integralno sa membranom Biološki proces • ćelijska adhezija • signalni put G protein spregnutog receptora • neuropeptidni signalni put • međućelijska signalizacija • moždani razvoj
Ortolozi
Vrsta	Čovek	Miš
Entrez	23284	319387
Ensembl	ENSG00000150471	ENSMUSG00000037605
UniProt	Q9HAR2	Q80TS3
RefSeq (mRNA)	NM_015236.4	NM_198702.2
RefSeq (protein)	NP_056051.2	NP_941991.1
Lokacija (UCSC)	Chr 4: 62.07 - 62.94 Mb	Chr 5: 81.45 - 82.25 Mb
PubMed pretraga	[1]	[2]

Latrofilin-3 je protein koji je kod ljudi kodiran LPHN3 genom.^[1][2]

Function

Ovaj protein je član latrofilinske familije G protein spregnutih receptora (GPCR). Latrofilini mogu da učestvuju u ćelijskoj adheziji i u prenosu signala. Endogeno proteolitičko razlaganje unutar cisteinom bogatog GPS (GPCR proteolizno mesto) domena proizvodi dve podjedinice (veliku ekstracelularnu N-terminalnu adhezionu jedinicu i podjedinicu koja je u znatno meri slična sa sekretinskom/kalcitoninskom familijom).^[2]

Klinički značaj

Jedna verzija ovog gena je povezana sa hiperkinetičkim poremećajem (ADHD).^[3]

Reference

1. Hayflick JS (Jan 2001). „A family of heptahelical receptors with adhesion-like domains: a marriage between two super families”. J Recept Signal Transduct Res 20 (2–3): 119–31. DOI:10.3109/10799890009150640. PMID 10994649. 
2. „Entrez Gene: LPHN3 latrophilin 3”. 
3. Arcos-Burgos M, Jain M, Acosta MT, et al. (November 2010). „A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication”. Mol. Psychiatry 15 (11): 1053–66. DOI:10.1038/mp.2010.6. PMID 20157310. ^{[mrtav link]}

Literatura

• Südhof TC (2001). „alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins”. Annu. Rev. Neurosci. 24: 933–62. DOI:10.1146/annurev.neuro.24.1.933. PMID 11520923. 
• Ushkaryov YA, Volynski KE, Ashton AC (2004). „The multiple actions of black widow spider toxins and their selective use in neurosecretion studies”. Toxicon 43 (5): 527–42. DOI:10.1016/j.toxicon.2004.02.008. PMID 15066411. 
• Soares MB, Bonaldo MF, Jelene P, et al. (1994). „Construction and characterization of a normalized cDNA library”. Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9228–32. DOI:10.1073/pnas.91.20.9228. PMC 44785. PMID 7937745. 
• „Toward a complete human genome sequence”. Genome Res. 8 (11): 1097–108. 1999. DOI:10.1101/gr.8.11.1097. PMID 9847074. 
• Nagase T, Ishikawa K, Suyama M, et al. (1999). „Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 5 (5): 277–86. DOI:10.1093/dnares/5.5.277. PMID 9872452. 
• Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). „The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins”. J. Biol. Chem. 275 (42): 32387–90. DOI:10.1074/jbc.C000490200. PMID 10964907. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). „The human and mouse repertoire of the adhesion family of G-protein-coupled receptors”. Genomics 84 (1): 23–33. DOI:10.1016/j.ygeno.2003.12.004. PMID 15203201. 

Povezano

• Latrofilinski receptor