Motilin receptor

edit

Motilin receptor
Identifikatori
Simboli	MLNR; GPR38; MTLR1
Vanjski ID	OMIM: 602885 HomoloGene: 74398 IUPHAR: motilin GeneCards: MLNR Gene
Ontologija gena Molekularna funkcija • rodopsinu-slična receptorska aktivnost • receptorska aktivnost • aktivnost hormon rasta-oslobađajućeg hormonskog receptora Celularna komponenta • integralno sa membranom plazme • membrana Biološki proces • kontrakcija glatkog mišića • prenos signal • G-protein spregnuti receptor protein signalni put • varenje
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2862	n/a
Ensembl	ENSG00000102539	n/a
UniProt	O43193	n/a
RefSeq (mRNA)	NM_001507	n/a
RefSeq (protein)	NP_001498	n/a
Lokacija (UCSC)	Chr 13: 48.69 - 48.69 Mb	n/a
PubMed pretraga	[1]	n/a

Motilin receptor je G protein-spregnuti receptor koji vezuje motilin.^[1][2] Motilin je intestinalni peptid koji stimuliše kontrakcije glatkih mišića stomaka.

Literatura

1. Depoortere I (2001). „Motilin and motilin receptors: characterization and functional significance”. Verh. K. Acad. Geneeskd. Belg. 63 (6): 511–29. PMID 11813507. 
2. Yang X, Dong L, Yang H (2006). „[Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons]” (Chinese). Sichuan Da Xue Xue Bao Yi Xue Ban 37 (5): 683–6. PMID 17037727. 

Dodatna literatura

• Smith RG, Leonard R, Bailey AR, et al. (2001). „Growth hormone secretagogue receptor family members and ligands.”. Endocrine 14 (1): 9–14. DOI:10.1385/ENDO:14:1:009. PMID 11322507. 
• McKee KK, Tan CP, Palyha OC, et al. (1998). „Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.”. Genomics 46 (3): 426–34. DOI:10.1006/geno.1997.5069. PMID 9441746. 
• Feighner SD, Tan CP, McKee KK, et al. (1999). „Receptor for motilin identified in the human gastrointestinal system.”. Science 284 (5423): 2184–8. DOI:10.1126/science.284.5423.2184. PMID 10381885. 
• Miller P, Roy A, St-Pierre S, et al. (2000). „Motilin receptors in the human antrum.”. Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G18–23. PMID 10644557. 
• Thielemans L, Depoortere I, Van Assche G, et al. (2001). „Demonstration of a functional motilin receptor in TE671 cells from human cerebellum.”. Brain Res. 895 (1-2): 119–28. DOI:10.1016/S0006-8993(01)02055-8. PMID 11259768. 
• Coulie B, Matsuura B, Dong M, et al. (2001). „Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.”. J. Biol. Chem. 276 (38): 35518–22. DOI:10.1074/jbc.M104489200. PMID 11461914. 
• Thielemans L, Depoortere I, Vanden Broeck J, Peeters TL (2002). „The motilin pharmacophore in CHO cells expressing the human motilin receptor.”. Biochem. Biophys. Res. Commun. 293 (4): 1223–7. DOI:10.1016/S0006-291X(02)00356-X. PMID 12054506. 
• Depoortere I, Thijs T, Thielemans L, et al. (2003). „Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum.”. J. Pharmacol. Exp. Ther. 305 (2): 660–7. DOI:10.1124/jpet.102.047563. PMID 12606621. 
• Dunham A, Matthews LH, Burton J, et al. (2004). „The DNA sequence and analysis of human chromosome 13.”. Nature 428 (6982): 522–8. DOI:10.1038/nature02379. PMC 2665288. PMID 15057823. 
• Matsuura B, Dong M, Naik S, et al. (2006). „Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.”. J. Biol. Chem. 281 (18): 12390–6. DOI:10.1074/jbc.M511921200. PMID 16531413. 
• „Motilin Receptors: Motilin”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2011-05-16. 

Spoljašnje veze

• MeSH Motilin+receptor