N2-(2-karboksietil)arginin sintaza
| N2-(2-karboksietil)arginin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.66 | ||||||||
| CAS broj | 250207-48-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N2-(2-karboksietil)arginin sintaza (EC 2.5.1.66, CEAS, N2-(2-karboksietil)arginin sintetaza, CEA sintetaza, gliceraldehid-3-fosfat:L-arginin 2-N-(2-hidroksi-3-oksopropil) transferaza (formira 2-karboksietil)) je enzim sa sistematskim imenom gliceraldehid-3-fosfat:L-arginin N2-(2-hidroksi-3-oksopropil) transferaza (formira 2-karboksietil).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
Za dejstvo ovog enzima je neophodan tiamin difosfat. On katalizuje prvi korak u biosintezi klavulanske kiseline.
- ↑ Caines, M.E.C., Elkins, J.M., Hewitson, K.S. and Schofield, C.J. (2004). „Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzymes in the clavulanic acid biosynthesis pathway”. J. Biol. Chem. 279: 5685-5692. PMID 14623876.
- ↑ Khaleeli, N., Li, R. and Townsend, C.A. (1999). „Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction”. J. Am. Chem. Soc. 121: 9223-9224.
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