N6-ciklopentiladenozin

N6-ciklopentil adenozin
	(2R,3R,4S,5R)-2-[6-(ciklopentilamino)purin-9-il]-5-(hidroksimetil)oksolan-3,4-diol
Identifikacija
CAS registarski broj	41552-82-3
PubChem	657378
Jmol-3D slike	Slika 1
SMILES
	C1CCC(C1)NC2=NC=NC3=C2N=CN3[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O
Svojstva
Molekulska formula	C15H21N5O4
Molarna masa	335.36 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

N⁶-ciklopentiladenozin (CPA) je lek koji deluje kao selektivni agonist adenozinskog A₁ receptora.^[3] On uglavnom ima kardiovaskularno dejstva sa samo suptilnim izmenama ponašanja.^[4] CPA je u širokoj upotrebi u naučnim istraživanjima adenozinskog receptora i korišten je za razvoj velike familije derivata.^[5]^[6]^[7]^[8]^[9]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Williams M, Braunwalder A, Erickson TJ (February 1986). „Evaluation of the binding of the A-1 selective adenosine radioligand, cyclopentyladenosine (CPA), to rat brain tissue”. Naunyn-Schmiedeberg's Archives of Pharmacology 332 (2): 179–83. DOI:10.1007/BF00511410. PMID 3703020.
↑ Coffin VL, Spealman RD (April 1987). „Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys”. The Journal of Pharmacology and Experimental Therapeutics 241 (1): 76–83. PMID 3572798.
↑ Zablocki JA, Wu L, Shryock J, Belardinelli L (2004). „Partial A(1) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation (AF)”. Current Topics in Medicinal Chemistry 4 (8): 839–54. DOI:10.2174/1568026043450998. PMID 15078215.
↑ Hutchinson SA, Scammells PJ (2004). „A(1) adenosine receptor agonists: medicinal chemistry and therapeutic potential”. Current Pharmaceutical Design 10 (17): 2021–39. DOI:10.2174/1381612043384204. PMID 15279543.
↑ Elzein E, Kalla R, Li X, Perry T, Marquart T, Micklatcher M, Li Y, Wu Y, Zeng D, Zablocki J (January 2007). „N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists”. Bioorganic & Medicinal Chemistry Letters 17 (1): 161–6. DOI:10.1016/j.bmcl.2006.09.065. PMID 17045477.
↑ Elzein E, Zablocki J (December 2008). „A1 adenosine receptor agonists and their potential therapeutic applications”. Expert Opinion on Investigational Drugs 17 (12): 1901–10. DOI:10.1517/13543780802497284. PMID 19012505.
↑ Franchetti P, Cappellacci L, Vita P, Petrelli R, Lavecchia A, Kachler S, Klotz KN, Marabese I, Luongo L, Maione S, Grifantini M (April 2009). „N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice”. Journal of Medicinal Chemistry 52 (8): 2393–406. DOI:10.1021/jm801456g. PMID 19317449.

Povezano

Spoljašnje veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid3703020-3] Williams M, Braunwalder A, Erickson TJ (February 1986). „Evaluation of the binding of the A-1 selective adenosine radioligand, cyclopentyladenosine (CPA), to rat brain tissue”. Naunyn-Schmiedeberg's Archives of Pharmacology 332 (2): 179–83. DOI:10.1007/BF00511410. PMID 3703020.

[pmid3572798-4] Coffin VL, Spealman RD (April 1987). „Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys”. The Journal of Pharmacology and Experimental Therapeutics 241 (1): 76–83. PMID 3572798.

[pmid15078215-5] Zablocki JA, Wu L, Shryock J, Belardinelli L (2004). „Partial A(1) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation (AF)”. Current Topics in Medicinal Chemistry 4 (8): 839–54. DOI:10.2174/1568026043450998. PMID 15078215.

[pmid15279543-6] Hutchinson SA, Scammells PJ (2004). „A(1) adenosine receptor agonists: medicinal chemistry and therapeutic potential”. Current Pharmaceutical Design 10 (17): 2021–39. DOI:10.2174/1381612043384204. PMID 15279543.

[pmid17045477-7] Elzein E, Kalla R, Li X, Perry T, Marquart T, Micklatcher M, Li Y, Wu Y, Zeng D, Zablocki J (January 2007). „N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists”. Bioorganic & Medicinal Chemistry Letters 17 (1): 161–6. DOI:10.1016/j.bmcl.2006.09.065. PMID 17045477.

[pmid19012505-8] Elzein E, Zablocki J (December 2008). „A1 adenosine receptor agonists and their potential therapeutic applications”. Expert Opinion on Investigational Drugs 17 (12): 1901–10. DOI:10.1517/13543780802497284. PMID 19012505.

[pmid19317449-9] Franchetti P, Cappellacci L, Vita P, Petrelli R, Lavecchia A, Kachler S, Klotz KN, Marabese I, Luongo L, Maione S, Grifantini M (April 2009). „N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice”. Journal of Medicinal Chemistry 52 (8): 2393–406. DOI:10.1021/jm801456g. PMID 19317449.

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