Neurolizin

Neurolizin
Identifikatori
EC broj	3.4.24.16
CAS broj	149371-24-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Neurolizin (EC 3.4.24.16, neurotensinska endopeptidaza, endopeptidaza 24.16, endo-oligopeptidaza B, prolinska-endopeptidaza) je enzim.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferentno razlaganje u neurotenzinu: Pro¹⁰-Tyr

Ovaj enzim deluje i na pojedine peptide, kao što su dinorfini 1-8, koji ne sadrže prolin.

Reference

1. Checler, F., Vincent, J.P. and Kitabgi, P. (1986). „Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes”. J. Biol. Chem. 261: 11274-11281. PMID 3525564. 
2. Barelli, H., Vincent, J.-P. and Checler, F. (1988). „Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum”. Eur. J. Biochem. 175: 481-489. PMID 3409880. 
3. Checler, F., Barelli, H. and Vincent, J.-P. (1989). „Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies”. Biochem. J. 257: 549-554. PMID 2649078. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Neurolysin