Neuromedinski B receptor
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| Neuromedinski B receptor | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | NMBR; | ||||||||||
| Vanjski ID | OMIM: 162341 MGI: 1100525 HomoloGene: 20560 IUPHAR: BB1 GeneCards: NMBR Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4829 | 18101 | |||||||||
| Ensembl | ENSG00000135577 | ENSMUSG00000019865 | |||||||||
| UniProt | P28336 | Q0VEH1 | |||||||||
| RefSeq (mRNA) | NM_002511 | NM_008703 | |||||||||
| RefSeq (protein) | NP_002502 | NP_032729 | |||||||||
| Lokacija (UCSC) | Chr 6: 142.44 - 142.45 Mb | Chr 10: 14.45 - 14.46 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Neuromedinski B receptor (NMBR), takođe poznat kao BB1 [1] je G protein-spregnuti receptor čiji je endogeni ligand neuromedin B[2].
Neuromedinski B receptor vezuje neuromedin B, potentni mitogen i faktor rasta za normalno i neoplastično tkivo pluća i gastrointestinalnog epitela.[3]
- ↑ „Bombesin Receptors: BB1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2013-10-04.
- ↑ Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). „Expression and characterization of cloned human bombesin receptors”. Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. Arhivirano iz originala na datum 2008-09-06. Pristupljeno 2014-05-08.
- ↑ „Entrez Gene: NMBR neuromedin B receptor”.
- Corjay MH, Dobrzanski DJ, Way JM, et al. (1991). „Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.”. J. Biol. Chem. 266 (28): 18771–9. PMID 1655761.
- Wu JM, Hoang DO, Feldman RI (1995). „Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs.”. Mol. Pharmacol. 47 (4): 871–81. PMID 7723750.
- Benya RV, Kusui T, Pradhan TK, et al. (1995). „Expression and characterization of cloned human bombesin receptors.”. Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.
- Bitar KN, Zhu XX (1994). „Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction.”. Gastroenterology 105 (6): 1672–80. PMID 8253343.
- Giladi E, Nagalla SR, Spindel ER (1993). „Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides.”. J. Mol. Neurosci. 4 (1): 41–54. DOI:10.1007/BF02736689. PMID 8391296.
- Fathi Z, Benya RV, Shapira H, et al. (1993). „The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding.”. J. Biol. Chem. 268 (20): 14622–6. PMID 8392057.
- Kane MA, Toi-Scott M, Johnson GL, et al. (1996). „Bombesin-like peptide receptors in human bronchial epithelial cells.”. Peptides 17 (1): 111–8. DOI:10.1016/0196-9781(95)02088-8. PMID 8822519.
- Sainz E, Akeson M, Mantey SA, et al. (1998). „Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor.”. J. Biol. Chem. 273 (26): 15927–32. DOI:10.1074/jbc.273.26.15927. PMID 9632639.
- Lee S, Kim Y (1999). „Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy.”. FEBS Lett. 460 (2): 263–9. DOI:10.1016/S0014-5793(99)01346-0. PMID 10544247.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Matusiak D, Glover S, Nathaniel R, et al. (2005). „Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon.”. Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718–28. DOI:10.1152/ajpgi.00156.2004. PMID 15528253.
- „Bombesin Receptors: BB1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2013-10-04.
- MeSH Receptors,+Bombesin