Pentoksiverin

Pentoksiverin
(IUPAC) ime
	2-[2-(diethylamino)ethoxy]ethyl 1-phenylcyclopentanecarboxylate
Klinički podaci
Identifikatori
CAS broj	77-23-6
ATC kod	R05DB05
PubChem	2562
ChemSpider	2464
KEGG	D08334
ChEMBL	CHEMBL73234
Hemijski podaci
Formula	C20H31NO3
Mol. masa	333.465 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H31NO3/c1-3-21(4-2)14-15-23-16-17-24-19(22)20(12-8-9-13-20)18-10-6-5-7-11-18/h5-7,10-11H,3-4,8-9,12-17H2,1-2H3 ; Key: CFJMRBQWBDQYMK-UHFFFAOYSA-N
Farmakokinetički podaci
Izlučivanje	Renalno
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	OTC (SAD)
Način primene	Oralno, rectalno

Pentoksiverin (INN), ili karbetapentan je supresant kašlja.^[6] On se prodaje na slobodno u SAD^[7], obično u kombinaciji sa drugim lekovima, naročito dekongestantima. On se često koristi za kašalj usled bolesti kao što je prehlada. Certuss je jedan takov proizvod koji sadrži kombinaciju guaifenesina i pentokisverina.

Pentoksiverin se ne preporučuje za upotrebu kod dece od 2 - 12 godina starosti.^[8]

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ „Pentoxyverine”. Pristupljeno 30. 04. 2011.
↑ Deisemann H, Ahrens N, Schlobohm I, Kirchhoff C, Netzer R, Möller C (December 2008). „Effects of common antitussive drugs on the hERG potassium channel current”. Journal of Cardiovascular Pharmacology 52 (6): 494–9. DOI:10.1097/FJC.0b013e31818eec8d. PMID 19034038. Pristupljeno 2011-04-30. ^{[mrtav link]}
↑ „TGA internal panel report on the safety, efficacy and use of cough and cold medicines in the treatment of children aged 2-12 years”. Arhivirano iz originala na datum 2011-03-03. Pristupljeno 30. 04. 2011.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[urlPentoxyverine_-_Drugs.com-6] „Pentoxyverine”. Pristupljeno 30. 04. 2011.

[pmid19034038-7] Deisemann H, Ahrens N, Schlobohm I, Kirchhoff C, Netzer R, Möller C (December 2008). „Effects of common antitussive drugs on the hERG potassium channel current”. Journal of Cardiovascular Pharmacology 52 (6): 494–9. DOI:10.1097/FJC.0b013e31818eec8d. PMID 19034038. Pristupljeno 2011-04-30. ^{[mrtav link]}

[urlwww.tga.gov.au-8] „TGA internal panel report on the safety, efficacy and use of cough and cold medicines in the treatment of children aged 2-12 years”. Arhivirano iz originala na datum 2011-03-03. Pristupljeno 30. 04. 2011.

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