S1PR4

Sfingozin 1-fosfat receptor 4
Dostupne strukture
	2DCO
Identifikatori
Simboli	S1PR4; EDG6; LPC1; S1P4; SLP4
Vanjski ID	OMIM: 603751 MGI: 1333809 HomoloGene: 2799 IUPHAR: S1P4 GeneCards: S1PR4 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora; • aktivnost faktora guanil-nukleotidne razmene; • vezivanje masne kiseline;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• metabolički proces energetske rezerve; • signalni put G-protein spregnutog receptora; • pozitivna regulacija kalcijumskog jonskog transporta u citozol;
Pregled RNK izražavanja
	podaci
Ortolozi

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Sfingozin 1-fosfatni receptor 4 (S1PR4) je ljudski gen koji kodira G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin 1-fosfat (S1P).^[1] Gen S1PR4 ne sadrži introne.

Funkcija

Ovaj protein učestvuje u endotelnoj diferencijaciji. Za njega se vezuju lizofosfolipidi ili lizosfingolipidi. On učestvuje u ćelijskoj signalizaciji mnogih ćelijskih tipova. Specifičan ze za limfoidna tkiva.^[1]

Reference

↑ ^1,0 ^1,1 „Entrez Gene: S1PR4 Sphingosine-1-phosphate receptor 4”.

Literatura

Gräler MH, Bernhardt G, Lipp M (1998). „EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue.”. Genomics 53 (2): 164–9. DOI:10.1006/geno.1998.5491. PMID 9790765.
Yamazaki Y, Kon J, Sato K, et al. (2000). „Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.”. Biochem. Biophys. Res. Commun. 268 (2): 583–9. DOI:10.1006/bbrc.2000.2162. PMID 10679247.
Van Brocklyn JR, Gräler MH, Bernhardt G, et al. (2000). „Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.”. Blood 95 (8): 2624–9. PMID 10753843.
Idzko M, Panther E, Corinti S, et al. (2002). „Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses.”. Faseb J. 16 (6): 625–7. PMID 11919175.
Kveberg L, Bryceson Y, Inngjerdingen M, et al. (2002). „Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases.”. Eur. J. Immunol. 32 (7): 1856–64. DOI:10.1002/1521-4141(200207)32:7<1856::AID-IMMU1856>3.0.CO;2-B. PMID 12115604.
Candelore MR, Wright MJ, Tota LM, et al. (2002). „Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.”. Biochem. Biophys. Res. Commun. 297 (3): 600–6. DOI:10.1016/S0006-291X(02)02237-4. PMID 12270137.
Contos JJ, Ye X, Sah VP, Chun J (2002). „Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene.”. FEBS Lett. 531 (1): 99–102. DOI:10.1016/S0014-5793(02)03409-9. PMID 12401211.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vogler R, Sauer B, Kim DS, et al. (2003). „Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.”. J. Invest. Dermatol. 120 (4): 693–700. DOI:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
Gräler MH, Grosse R, Kusch A, et al. (2003). „The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13.”. J. Cell. Biochem. 89 (3): 507–19. DOI:10.1002/jcb.10537. PMID 12761884.
Kyi CS, Key SJ, Lloyd TW (2003). „Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm.”. International journal of oral and maxillofacial surgery 32 (3): 337–8. DOI:10.1054/ijom.2003.0364. PMID 12767884.
Holdsworth G, Osborne DA, Pham TT, et al. (2005). „A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor.”. BMC Biochem. 5: 12. DOI:10.1186/1471-2091-5-12. PMID 15298705.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.

Spoljašnje veze

„Lysophospholipid Receptors: S₁P₄”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
MeSH Lysophospholipid+receptors

Povezano

Lizofosfolipidni receptor

[entrez-1] 1,0 ^1,1 „Entrez Gene: S1PR4 Sphingosine-1-phosphate receptor 4”.

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