CALCRL

Kalcitoninu sličan receptor
Kalcitoninu sličan receptor
	Kristalografksa struktura ektodomenskog kompleksa CGRP tip 1 receptora i RAMP1.
Dostupne strukture
	3AQF, 3N7P, 3N7R, 3N7S
Identifikatori
Simboli	CALCRL; CGRPR; CRLR
Vanjski ID	OMIM: 114190 MGI: 1926944 HomoloGene: 21179 IUPHAR: CALCRL GeneCards: CALCRL Gene
Ontologija gena
Molekularna funkcija	• aktivnost adrenomedulinskog receptora; • aktivnost kalcitoninu sličnog receptora; • aktivnost G-protein spregnutog receptora;
Celularna komponenta	• lizozom; • endozom; • endoplaszmični retikulum; • ćelijska membrana;
Biološki proces	• angiogeneza; • cAMP biosintetički proces; • transport kalcijumskih jona; • regulacija mišićne kontrakcije;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	10203
Ensembl	ENSG00000064989
UniProt	Q16602
RefSeq (mRNA)	NM_005795.4
RefSeq (protein)	NP_005786.1
Lokacija (UCSC)	Chr 2:; 188.21 - 188.31 Mb
PubMed pretraga	[1]

Kalcitoninskom receptoru sličan receptor (CALCRL, CRLR) je ljudski protein.^[2]

Funkcija

Ovaj protein je G protein spregnuti receptor, koji je srodan sa kalcitoninskim receptorom. CALCRL je vezan za jedan od tri jednoprolazna transmembranska domena modifikujućeg protena receptorske aktivnosti (RAMP) koji su esencijalni ja njegovo dejstvo.

Asocijacija CALCRL sa različitim RAMP proteinima proizvodi različite receptore:^[3]^[4]

sa RAMP1: proizvodi CGRP receptor
sa RAMP2: proizvodi adrenomedullinski (AM) receptor, koji je označava AM₁^[5]
sa RAMP3: proizvodi dvojni CGRP/AM receptor, sa oznakom AM₂

Ti receptori formiraju interakcije sa G proteinom G_s,^[6] koji aktivira adenilat ciklazu posledica čega je formiranje intracelularnog cikličnog adenozin monofosfata (cAMP).

Reference

^ PDB: 3N7S; ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM (2010). „Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism”. Structure. 18 (9): 1083—93. PMID 20826335. doi:10.1016/j.str.2010.05.014.
^ Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (1996). „A cDNA encoding the calcitonin gene-related peptide type 1 receptor”. J. Biol. Chem. 271 (19): 11325—9. PMID 8626685. doi:10.1074/jbc.271.19.11325.
^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (1998). „RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor”. Nature. 393 (6683): 333—9. PMID 9620797. doi:10.1038/30666.
^ Foord SM, Marshall FH (1999). „RAMPs: accessory proteins for seven transmembrane domain receptors”. Trends Pharmacol. Sci. 20 (5): 184—7. PMID 10354609. doi:10.1016/S0165-6147(99)01347-4.
^ Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T (1999). „The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells”. FEBS Lett. 448 (1): 111—4. PMID 10217420. doi:10.1016/S0014-5793(99)00358-0.
^ „Receptor properties”. SenseLab Project: Membrane properties resource. Yale University. Архивирано из оригинала 28. 02. 2009. г. Приступљено 28. 09. 2008.

Literatura

Born W, Muff R, Fischer JA (2002). „Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins (RAMP).”. Microsc. Res. Tech. 57 (1): 14—22. PMID 11921352. doi:10.1002/jemt.10051.
Yallampalli C; Chauhan M; Thota CS; et al. (2003). „Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity.”. Trends Endocrinol. Metab. 13 (6): 263—9. PMID 12128288.
Foord SM, Craig RK (1988). „Isolation and characterisation of a human calcitonin-gene-related-peptide receptor.”. Eur. J. Biochem. 170 (1-2): 373—9. PMID 2826160. doi:10.1111/j.1432-1033.1987.tb13710.x.
Skofitsch G, Jacobowitz DM (1986). „Autoradiographic distribution of 125I calcitonin gene-related peptide binding sites in the rat central nervous system.”. Peptides. 6 (5): 975—86. PMID 3001670. doi:10.1016/0196-9781(85)90331-6.
Flühmann B; Muff R; Hunziker W; et al. (1995). „A human orphan calcitonin receptor-like structure.”. Biochem. Biophys. Res. Commun. 206 (1): 341—7. PMID 7818539. doi:10.1006/bbrc.1995.1047.
Aiyar N; Rand K; Elshourbagy NA; et al. (1996). „A cDNA encoding the calcitonin gene-related peptide type 1 receptor.”. J. Biol. Chem. 271 (19): 11325—9. PMID 8626685. doi:10.1074/jbc.271.19.11325.
McLatchie LM; Fraser NJ; Main MJ; et al. (1998). „RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.”. Nature. 393 (6683): 333—9. PMID 9620797. doi:10.1038/30666.
Sams A, Jansen-Olesen I (1999). „Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries.”. Neurosci. Lett. 258 (1): 41—4. PMID 9876047. doi:10.1016/S0304-3940(98)00844-1.
Kamitani S; Asakawa M; Shimekake Y; et al. (1999). „The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells.”. FEBS Lett. 448 (1): 111—4. PMID 10217420. doi:10.1016/S0014-5793(99)00358-0.
Aldecoa A, Gujer R, Fischer JA, Born W (2000). „Mammalian calcitonin receptor-like receptor/receptor activity modifying protein complexes define calcitonin gene-related peptide and adrenomedullin receptors in Drosophila Schneider 2 cells.”. FEBS Lett. 471 (2-3): 156—60. PMID 10767413. doi:10.1016/S0014-5793(00)01387-9.
Frayon S; Cueille C; Gnidéhou S; et al. (2000). „Dexamethasone increases RAMP1 and CRLR mRNA expressions in human vascular smooth muscle cells.”. Biochem. Biophys. Res. Commun. 270 (3): 1063—7. PMID 10772950. doi:10.1006/bbrc.2000.2552.
Kuwasako K; Shimekake Y; Masuda M; et al. (2000). „Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling.”. J. Biol. Chem. 275 (38): 29602—9. PMID 10882736. doi:10.1074/jbc.M004534200.
Evans BN; Rosenblatt MI; Mnayer LO; et al. (2000). „CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors.”. J. Biol. Chem. 275 (40): 31438—43. PMID 10903324. doi:10.1074/jbc.M005604200.
Hilairet S, Foord SM, Marshall FH, Bouvier M (2001). „Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins.”. J. Biol. Chem. 276 (31): 29575—81. PMID 11387328. doi:10.1074/jbc.M102722200.
Kamitani S, Sakata T (2001). „Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling.”. Biochim. Biophys. Acta. 1539 (1-2): 131—9. PMID 11389975. doi:10.1016/S0167-4889(01)00100-8.
Nikitenko LL; Brown NS; Smith DM; et al. (2001). „Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus.”. Mol. Hum. Reprod. 7 (7): 655—64. PMID 11420389. doi:10.1093/molehr/7.7.655.
Hilairet S; Bélanger C; Bertrand J; et al. (2001). „Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin.”. J. Biol. Chem. 276 (45): 42182—90. PMID 11535606. doi:10.1074/jbc.M107323200.
Aiyar N, Disa J, Pullen M, Nambi P (2002). „Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells.”. Mol. Cell. Biochem. 224 (1-2): 123—33. PMID 11693189. doi:10.1023/A:1011907328682.
Hagner S; Haberberger RV; Overkamp D; et al. (2002). „Expression and distribution of calcitonin receptor-like receptor in human hairy skin.”. Peptides. 23 (1): 109—16. PMID 11814625. doi:10.1016/S0196-9781(01)00586-1.

Spoljašnje veze

„Calcitonin receptors: CALCRL”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
calcitonin+receptor-like+receptor на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid20826335-1] PDB: 3N7S; ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM (2010). „Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism”. Structure. 18 (9): 1083—93. PMID 20826335. doi:10.1016/j.str.2010.05.014.

[pmid8626685-2] Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (1996). „A cDNA encoding the calcitonin gene-related peptide type 1 receptor”. J. Biol. Chem. 271 (19): 11325—9. PMID 8626685. doi:10.1074/jbc.271.19.11325.

[pmid9620797-3] McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (1998). „RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor”. Nature. 393 (6683): 333—9. PMID 9620797. doi:10.1038/30666.

[pmid10354609-4] Foord SM, Marshall FH (1999). „RAMPs: accessory proteins for seven transmembrane domain receptors”. Trends Pharmacol. Sci. 20 (5): 184—7. PMID 10354609. doi:10.1016/S0165-6147(99)01347-4.

[pmid10217420-5] Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T (1999). „The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells”. FEBS Lett. 448 (1): 111—4. PMID 10217420. doi:10.1016/S0014-5793(99)00358-0.

[urlReceptor_properties-6] „Receptor properties”. SenseLab Project: Membrane properties resource. Yale University. Архивирано из оригинала 28. 02. 2009. г. Приступљено 28. 09. 2008.

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