Cisteinil leukotrienski receptor 2

Cisteinil leukotrienski receptor 2
Cisteinil leukotrienski receptor 2
Identifikatori
Simboli	CYSLTR2; CYSLT2; CYSLT2R; HG57; HPN321; KPG_011; hGPCR21
Vanjski ID	OMIM: 605666 MGI: 1917336 HomoloGene: 10688 IUPHAR: CysLT2 GeneCards: CYSLTR2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost prenosa signala; • receptorska aktivnost; • aktivnost leukotrienskog receptora;
Celularna komponenta	• membranska frakcija; • ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• transport kalcijumskih jona; • hemotaksa; • odbrambeni respons; • inflamatorni respons; • povišenje koncentracije citozolinih kalcijumovih jona; • razmena respiratornih gasova; • pozitivna regulacija vazokonstrikcije;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	57105
Ensembl	ENSG00000152207
UniProt	Q9NS75
RefSeq (mRNA)	NM_020377.2
RefSeq (protein)	NP_065110.1
Lokacija (UCSC)	Chr 13:; 49.28 - 49.28 Mb
PubMed pretraga	[1]

Cisteinil leukotrienski receptor 2 je protein koji je kod ljudi kodiran CYSLTR2 genom.^[1]^[2]^[3]

Cisteinil leukotrieni LTC4, LTD4, i LTE4 sz važni posrednici ljudske bronhijalne astme. Farmakološka ispitivanja su utvrdila da cisteinil leukotrieni aktiviraju najmanje 2 receptora, protein kodiran ovim genom i CYSLTR1. Ovaj receptor je član superfamilije G protein spregnutih receptora. On je deo endokrinnih i kardiovaskularnih sistema.^[3]

Reference

^ Takasaki J, Kamohara M, Matsumoto M, Saito T, Sugimoto T, Ohishi T, Ishii H, Ota T, Nishikawa T, Kawai Y, Masuho Y, Isogai T, Suzuki Y, Sugano S, Furuichi K (2000). „The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor”. Biochem Biophys Res Commun. 274 (2): 316—22. PMID 10913337. doi:10.1006/bbrc.2000.3140.
^ Van Keer C, Kersters K, De Ley J (1976). „L-Sorbose metabolism in Agrobacterium tumefaciens”. Antonie Van Leeuwenhoek. 42 (1–2): 13—24. PMID 1085123. doi:10.1007/BF00399445.
^ ^а ^б „Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2”.

Literatura

Nothacker HP; Wang Z; Zhu Y; et al. (2001). „Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist”. Mol. Pharmacol. 58 (6): 1601—8. PMID 11093801.
Mita H, Hasegawa M, Saito H, Akiyama K (2002). „Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils”. Clin. Exp. Allergy. 31 (11): 1714—23. PMID 11696047. doi:10.1046/j.1365-2222.2001.01184.x.
Takeda S; Kadowaki S; Haga T; et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence”. FEBS Lett. 520 (1–3): 97—101. PMID 12044878. doi:10.1016/S0014-5793(02)02775-8.
Shirasaki H; Kanaizumi E; Watanabe K; et al. (2003). „Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa”. Clin. Exp. Allergy. 32 (7): 1007—12. PMID 12100046. doi:10.1046/j.1365-2222.2002.01425.x.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Sjöström M; Johansson AS; Schröder O; et al. (2004). „Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells”. Arterioscler. Thromb. Vasc. Biol. 23 (8): e37—41. PMID 12816881. doi:10.1161/01.ATV.0000082689.46538.DF.
Mellor EA; Frank N; Soler D; et al. (2003). „Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R”. Proc. Natl. Acad. Sci. U.S.A. 100 (20): 11589—93. PMC 208802 . PMID 13679572. doi:10.1073/pnas.2034927100.
Thompson MD; Storm van's Gravesande K; Galczenski H; et al. (2004). „A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha”. Pharmacogenetics. 13 (10): 641—9. PMID 14515063. doi:10.1097/01.fpc.0000054127.14659.42.
Dunham A; Matthews LH; Burton J; et al. (2004). „The DNA sequence and analysis of human chromosome 13”. Nature. 428 (6982): 522—8. PMC 2665288 . PMID 15057823. doi:10.1038/nature02379.
Fukai H; Ogasawara Y; Migita O; et al. (2005). „Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma”. Pharmacogenetics. 14 (10): 683—90. PMID 15454733. doi:10.1097/00008571-200410000-00006.
Pillai SG; Cousens DJ; Barnes AA; et al. (2005). „A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma”. Pharmacogenetics. 14 (9): 627—33. PMID 15475736. doi:10.1097/00008571-200409000-00007.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Hui Y; Cheng Y; Smalera I; et al. (2005). „Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure”. Circulation. 110 (21): 3360—6. PMID 15545522. doi:10.1161/01.CIR.0000147775.50954.AA.
Corrigan C; Mallett K; Ying S; et al. (2005). „Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis”. J. Allergy Clin. Immunol. 115 (2): 316—22. PMID 15696087. doi:10.1016/j.jaci.2004.10.051.
Uzonyi B; Lötzer K; Jahn S; et al. (2006). „Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells”. Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6326—31. PMC 1458877 . PMID 16606835. doi:10.1073/pnas.0601223103.
Woszczek G; Chen LY; Nagineni S; et al. (2007). „IFN-gamma induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes”. J. Immunol. 178 (8): 5262—70. PMID 17404310.
Klotsman M; York TP; Pillai SG; et al. (2007). „Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast”. Pharmacogenet. Genomics. 17 (3): 189—96. PMID 17460547. doi:10.1097/FPC.0b013e3280120043.

Vidi još

Eikozanoidni receptor

Spoljašnje veze

„Leukotriene Receptors: CysLT₂”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.

[pmid10913337-1] Takasaki J, Kamohara M, Matsumoto M, Saito T, Sugimoto T, Ohishi T, Ishii H, Ota T, Nishikawa T, Kawai Y, Masuho Y, Isogai T, Suzuki Y, Sugano S, Furuichi K (2000). „The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor”. Biochem Biophys Res Commun. 274 (2): 316—22. PMID 10913337. doi:10.1006/bbrc.2000.3140.

[pmid1085123-2] Van Keer C, Kersters K, De Ley J (1976). „L-Sorbose metabolism in Agrobacterium tumefaciens”. Antonie Van Leeuwenhoek. 42 (1–2): 13—24. PMID 1085123. doi:10.1007/BF00399445.

[entrez-3] а ^б „Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2”.

[1]

[2]

[3]