FSH-receptor

Struktura interakcije FSH i FSH-receptora
Struktura interakcije FSH i FSH-receptora
	PDB prikaz baziran na 1xwd.
Dostupne strukture
	1xwd
Identifikatori
Simboli	FSHR; FSHRO; LGR1; MGC141667; MGC141668; ODG1
Vanjski ID	OMIM: 136435 MGI: 95583 HomoloGene: 117 IUPHAR: FSH GeneCards: FSHR Gene
Ontologija gena
Molekularna funkcija	• aktivnost receptora; • aktivnost folikulostimulišućeg hormonskog receptora; • proteinsko vezivanje;
Celularna komponenta	• ćelijska membrana; • integralno sa membranom;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • spermatogeneza; • generisanje ženskog gameta; • razvoj ženskog gonada;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	2492
Ensembl	ENSG00000170820
UniProt	P23945
RefSeq (mRNA)	NM_000145
RefSeq (protein)	NP_000136
Lokacija (UCSC)	Chr 2:; 49.04 - 49.24 Mb
PubMed pretraga	[1]

Folikulostimulišući hormonski receptor ili FSH-receptor (FSHR) je transmembranski receptor koji interaguje sa Folikulostimulišućim hormonom (FSH). On je G protein-spregnuti receptor (GPCR). Njegova aktivacija je neophodna za FSH hormonsko funkcionisanje. FSHR receptori su nađeni u jajnicima, testisima, i uterusu.

FSHR gen

FSHR gen se nalazi na hromozomu 2 p21 kod čoveka. FSHR genska sekvenca se sastoji od oko 2,080 nukleotida.^[1]

Struktura receptora

FSHR se sastoji od 695 aminokiselina, i ima molekulsku masu od oko 76 kDa.^[1] Poput drugih GPCR receptora, FSH-receptor poseduje sedam domena (transmembranskih heliksa), svaki od kojih premoštava membranu.

Ekstracelularni domen receptora je glikoziliran.
Transmembranski domen sadrži dva visoko očuvana cisteinska ostatka koji formiraju disulfidnu vezs čime se stabilizuje struktura receptora. Visoko konzervirani Asp-Arg-Tyr triplet je prisutan i verovatno učestvuje u prenosu signala.
C-terminalni domen je intraćelijski i kratak. On bogat u ostacima serina i treonina koji služe kao moguća mesta za fosforilaciju.

Reference

^ ^а ^б Simoni M, Gromoll J, Nieschlag E (1997). „The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology”. Endocr. Rev. 18 (6): 739—73. PMID 9408742. doi:10.1210/er.18.6.739.

Literatura

de la Chapelle A (1993). „Disease gene mapping in isolated human populations: the example of Finland.”. J. Med. Genet. 30 (10): 857—65. PMC 1016570 . PMID 8230163. doi:10.1136/jmg.30.10.857.
Amsterdam A; Hanoch T; Dantes A; et al. (2003). „Mechanisms of gonadotropin desensitization.”. Mol. Cell. Endocrinol. 187 (1-2): 69—74. PMID 11988313. doi:10.1016/S0303-7207(01)00701-8.
Simoni M, Nieschlag E, Gromoll J (2003). „Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction.”. Hum. Reprod. Update. 8 (5): 413—21. PMID 12398222. doi:10.1093/humupd/8.5.413.
Delbaere A; Smits G; Olatunbosun O; et al. (2004). „New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?”. Hum. Reprod. 19 (3): 486—9. PMC 2891954 . PMID 14998941. doi:10.1093/humrep/deh124.
Bose CK (2005). „Role of nerve growth factor and FSH receptor in epithelial ovarian cancer.”. Reprod. Biomed. Online. 11 (2): 194—7. PMID 16168216. doi:10.1016/S1472-6483(10)60958-3.
Wunsch A, Sonntag B, Simoni M (2007). „Polymorphism of the FSH receptor and ovarian response to FSH.”. Ann. Endocrinol. (Paris). 68 (2-3): 160—6. PMID 17544358. doi:10.1016/j.ando.2007.04.006.
Kelton CA; Cheng SV; Nugent NP; et al. (1993). „The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells.”. Mol. Cell. Endocrinol. 89 (1-2): 141—51. PMID 1301382. doi:10.1016/0303-7207(92)90220-Z.
Tilly JL; Aihara T; Nishimori K; et al. (1992). „Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts.”. Endocrinology. 131 (2): 799—806. PMID 1322283. doi:10.1210/en.131.2.799.
Gromoll J, Gudermann T, Nieschlag E (1992). „Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor.”. Biochem. Biophys. Res. Commun. 188 (3): 1077—83. PMID 1359889. doi:10.1016/0006-291X(92)91341-M.
Minegishi T; Nakamura K; Takakura Y; et al. (1991). „Cloning and sequencing of human FSH receptor cDNA.”. Biochem. Biophys. Res. Commun. 175 (3): 1125—30. PMID 1709010. doi:10.1016/0006-291X(91)91682-3.
Gromoll J; Ried T; Holtgreve-Grez H; et al. (1994). „Localization of the human FSH receptor to chromosome 2 p21 using a genomic probe comprising exon 10.”. J. Mol. Endocrinol. 12 (3): 265—71. PMID 7916967. doi:10.1677/jme.0.0120265.
Gromoll J, Dankbar B, Gudermann T (1994). „Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene.”. Mol. Cell. Endocrinol. 102 (1-2): 93—102. PMID 7926278. doi:10.1016/0303-7207(94)90102-3.
Rousseau-Merck MF; Atger M; Loosfelt H; et al. (1993). „The chromosomal localization of the human follicle-stimulating hormone receptor gene (FSHR) on 2p21-p16 is similar to that of the luteinizing hormone receptor gene.”. Genomics. 15 (1): 222—4. PMID 8432542. doi:10.1006/geno.1993.1041.
Jiang X; Dreano M; Buckler DR; et al. (1996). „Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.”. Structure. 3 (12): 1341—53. PMID 8747461. doi:10.1016/S0969-2126(01)00272-6.
Aittomäki K; Herva R; Stenman UH; et al. (1996). „Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene.”. J. Clin. Endocrinol. Metab. 81 (10): 3722—6. PMID 8855829. doi:10.1210/jc.81.10.3722.
Tapanainen JS; Aittomäki K; Min J; et al. (1997). „Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility.”. Nat. Genet. 15 (2): 205—6. PMID 9020851. doi:10.1038/ng0297-205.
Kotlar TJ; Young RH; Albanese C; et al. (1997). „A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.”. J. Clin. Endocrinol. Metab. 82 (4): 1020—6. PMID 9100567. doi:10.1210/jc.82.4.1020.

Vidi još

Luteinizirajući hormon/horiogonadotropin receptor

Spoljašnje veze

„Glycoprotein Hormone Receptors: FSH”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 07. 04. 2014. г.
GRIS: Glycoprotein-hormone Receptor Information System

[FSHR-1] а ^б Simoni M, Gromoll J, Nieschlag E (1997). „The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology”. Endocr. Rev. 18 (6): 739—73. PMID 9408742. doi:10.1210/er.18.6.739.

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