KF-26777

KF-26777
IUPAC ime
	(2-(4-bromofenil)-7,8-dihidro-4-propil-1H-imidazo[2,1-i]purin-5(4H)-on
Identifikatori
ATC kod	none
Sinonimi	KF-26777
Hemijski podaci
Formula	C16H18BrN5O
Molarna masa	376,250 g/mol
	SMILES CCCN(C2=O)C1N=C(c(cc3)ccc3Br)NC1C=4N2CCN=4; ;

KF-26777 je lek koji deluje kao potentan i selektivan antagonist adenozinskog A₃ receptora, nanomolarnim afinitetom (A₃ Ki=0.2nM) i visokom selektivnošću u odnosu na druge adenozinske receptore.^[1] Jednostavni ksantinski derivati kao što je kofein i DPCPX generalno imaju nizak afinitet za A₃ receptor, te moraju da budu prošireni dodatkom aromatične grupe.^[2]

Reference

^ Saki M, Tsumuki H, Nonaka H, Shimada J, Ichimura M (2002). „KF26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one dihydrochloride), a new potent and selective adenosine A3 receptor antagonist”. European Journal of Pharmacology. 444 (3): 133—41. PMID 12063073. doi:10.1016/S0014-2999(02)01662-X.
^ Baraldi PG, Tabrizi MA, Gessi S, Borea PA (2008). „Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility”. Chemical Reviews. 108 (1): 238—63. PMID 18181659. doi:10.1021/cr0682195.

Spoljašnje veze

[pmid12063073-1] Saki M, Tsumuki H, Nonaka H, Shimada J, Ichimura M (2002). „KF26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one dihydrochloride), a new potent and selective adenosine A3 receptor antagonist”. European Journal of Pharmacology. 444 (3): 133—41. PMID 12063073. doi:10.1016/S0014-2999(02)01662-X.

[pmid18181659-2] Baraldi PG, Tabrizi MA, Gessi S, Borea PA (2008). „Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility”. Chemical Reviews. 108 (1): 238—63. PMID 18181659. doi:10.1021/cr0682195.

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