LPHN2

Latrofilin 2
Latrofilin 2
Identifikatori
Simboli	LPHN2; CIRL2; CL2; LEC1; LPHH1
Vanjski ID	OMIM: 607018 MGI: 2139714 HomoloGene: 22712 IUPHAR: LPHN2 GeneCards: LPHN2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • proteinsko vezivanje;
Celularna komponenta	• integralno sa ćelijskom membranom; • integralno sa membranom;
Biološki proces	• ćelijska adhezija; • signalni put G protein spregnutog receptora; • neuropeptidni signalni put;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	23266
Ensembl	ENSG00000117114
UniProt	O95490
RefSeq (mRNA)	NM_012302.2
RefSeq (protein)	NP_036434.1
Lokacija (UCSC)	Chr 1:; 81.77 - 82.46 Mb
PubMed pretraga	[1]

Latrofilin-2 je protein koji je kod ljudi kodrian LPHN2 genom.^[1]^[2]

Ovaj protein je član latrofilinske familije G protein spregnutih receptora (GPCR). Latrofilini mogu da učestvuju u ćelijskoj adheziji i u prenosu signala. Endogeno proteolitičko razlaganje unutar cisteinom bogatog GPS (GPCR proteolizno mesto) domena proizvodi dve podjedinice (veliku ekstracelularnu N-terminalnu adhezionu jedinicu i podjedinicu koja je u znatno meri slična sa sekretinskom/kalcitoninskom familijom). Ovi domeni su nekovalentno vezani na ćelijskoj membrani. Dok je nekoliko transkriptnih varijanti poznato, do sada je samo jedna biološki okarakterisana.^[2]

Reference

^ White GR, Varley JM, Heighway J (2000). „Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines”. Biochim Biophys Acta. 1491 (1-3): 75—92. PMID 10760572.
^ ^а ^б „Entrez Gene: LPHN2 latrophilin 2”.

Literatura

Südhof TC (2001). „alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.”. Annu. Rev. Neurosci. 24 (1): 933—62. PMID 11520923. doi:10.1146/annurev.neuro.24.1.933.
Ushkaryov YA, Volynski KE, Ashton AC (2004). „The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.”. Toxicon. 43 (5): 527—42. PMID 15066411. doi:10.1016/j.toxicon.2004.02.008.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791—806. PMID 8889548. doi:10.1101/gr.6.9.791.
Nagase T; Ishikawa K; Suyama M; et al. (1999). „Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”. DNA Res. 5 (5): 277—86. PMID 9872452. doi:10.1093/dnares/5.5.277.
White GR, Varley JM, Heighway J (1999). „Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer.”. Oncogene. 17 (26): 3513—9. PMID 10030676. doi:10.1038/sj.onc.1202487.
Kreienkamp HJ; Zitzer H; Gundelfinger ED; et al. (2000). „The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.”. J. Biol. Chem. 275 (42): 32387—90. PMID 10964907. doi:10.1074/jbc.C000490200.
Bjarnadóttir TK; Fredriksson R; Höglund PJ; et al. (2005). „The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.”. Genomics. 84 (1): 23—33. PMID 15203201. doi:10.1016/j.ygeno.2003.12.004.
Gregory SG; Barlow KF; McLay KE; et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”. Nature. 441 (7091): 315—21. PMID 16710414. doi:10.1038/nature04727.
Clark TA; Schweitzer AC; Chen TX; et al. (2007). „Discovery of tissue-specific exons using comprehensive human exon microarrays.”. Genome Biol. 8 (4): R64. PMC 1896007 . PMID 17456239. doi:10.1186/gb-2007-8-4-r64.

Vidi još

Latrofilinski receptor

[pmid10760572-1] White GR, Varley JM, Heighway J (2000). „Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines”. Biochim Biophys Acta. 1491 (1-3): 75—92. PMID 10760572.

[entrez-2] а ^б „Entrez Gene: LPHN2 latrophilin 2”.

[1]

[2]