Moždano specifični angiogenezni inhibitor 1

Moždano specifični angiogenezni inhibitor 1
Moždano specifični angiogenezni inhibitor 1
Identifikatori
Simboli	BAI1; GDAIF
Vanjski ID	OMIM: 602682 MGI: 1933736 HomoloGene: 1287 IUPHAR: BAI1 GeneCards: BAI1 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora; • proteinsko vezivanje;
Celularna komponenta	• citoplazma; • ćelijska membrana; • integralno sa ćelijskom membranom; • ćelijska površina;
Biološki proces	• ćelijska adhezija; • signalni put G-protein spregnutog receptora; • prenos signala; • neuropeptidni signalni put;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	575
Ensembl	ENSG00000181790
UniProt	O14514
RefSeq (mRNA)	NM_001702.2
RefSeq (protein)	NP_001693.2
Lokacija (UCSC)	Chr 8:; 143.53 - 143.63 Mb
PubMed pretraga	[1]

Moždano specifični angiogenezni inhibitor 1 je protein koji je kod ljudi kodiran BAI1 genom.^[1]^[2] On je inhibitor angiogeneze i supresor rasta glioblastoma.^[2]

Angiogeneza je kontrolisana lokalnim balansom između stimulatora i inhibitora rasta novih krvnih sudova, i supresovana je pod normalnim fiziološkim uslovima. Angiogeneza je esencijalna za rast i metastazu čvrstih tumora. Da bi obezbedile snabdevanje krvi koji je neophodno za njihov rast, ćelije tumora su potentno angiogene i privlače nove krvne sudove usled povišene sekrecije induktivnih agenasa i umanjene produkcije endogenih negativnih regulatora. BAI1 sadrži najmanje jedano funkcionalno p53 mesto vezivanja unutar introna, i njegovo izražavanje može da bude indukovano p53 faktorom. Postoje dva druga gena moždano specifičnih angiogeneznih inhibitor, BAI2 i BAI3, koji zajedno sa BAI1 imaju slične tkivne karakteristike i strukture, međutim samo BAI1 je transkripciono regulisan p53 proteinom. BAI1 je član sekretinske receptorske familije.

Interakcije

Moždano specifični angiogenezni inhibitor 1 formira interakcije sa BAIAP3^[3] i MAGI1.^[4]

Reference

^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (1998). „Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)”. Cytogenet Cell Genet. 79 (1–2): 103—8. PMID 9533023. doi:10.1159/000134693.
^ ^а ^б „Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1”.
^ Shiratsuchi, T; Oda K; et al. (1998). „Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1”. Biochem. Biophys. Res. Commun. UNITED STATES. 251 (1): 158—65. ISSN 0006-291X. PMID 9790924. doi:10.1006/bbrc.1998.9408.
^ Shiratsuchi, T; Futamura M; et al. (1998). „Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1”. Biochem. Biophys. Res. Commun. UNITED STATES. 247 (3): 597—604. ISSN 0006-291X. PMID 9647739. doi:10.1006/bbrc.1998.8603.

Literatura

Van Meir EG; Polverini PJ; Chazin VR; et al. (1995). „Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells”. Nat. Genet. 8 (2): 171—6. PMID 7531056. doi:10.1038/ng1094-171.
Nishimori H; Shiratsuchi T; Urano T; et al. (1997). „A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis”. Oncogene. 15 (18): 2145—50. PMID 9393972. doi:10.1038/sj.onc.1201542.
Shiratsuchi T; Futamura M; Oda K; et al. (1998). „Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1”. Biochem. Biophys. Res. Commun. 247 (3): 597—604. PMID 9647739. doi:10.1006/bbrc.1998.8603.
Fukushima Y; Oshika Y; Tsuchida T; et al. (1998). „Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer”. Int. J. Oncol. 13 (5): 967—70. PMID 9772287.
Shiratsuchi T; Oda K; Nishimori H; et al. (1998). „Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1”. Biochem. Biophys. Res. Commun. 251 (1): 158—65. PMID 9790924. doi:10.1006/bbrc.1998.9408.
Oda K; Shiratsuchi T; Nishimori H; et al. (1999). „Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1”. Cytogenet. Cell Genet. 84 (1–2): 75—82. PMID 10343108. doi:10.1159/000015219.
Wu Y; Dowbenko D; Spencer S; et al. (2000). „Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase”. J. Biol. Chem. 275 (28): 21477—85. PMID 10748157. doi:10.1074/jbc.M909741199.
Koh JT; Lee ZH; Ahn KY; et al. (2001). „Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein”. Brain Res. Mol. Brain Res. 87 (2): 223—37. PMID 11245925. doi:10.1016/S0169-328X(01)00004-3.
Duda DG; Sunamura M; Lozonschi L; et al. (2002). „Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis”. Br. J. Cancer. 86 (3): 490—6. PMC 2375213 . PMID 11875720. doi:10.1038/sj.bjc.6600067.
Lim IA, Hall DD, Hell JW (2002). „Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102”. J. Biol. Chem. 277 (24): 21697—711. PMID 11937501. doi:10.1074/jbc.M112339200.
Mori K; Kanemura Y; Fujikawa H; et al. (2002). „Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells”. Neurosci. Res. 43 (1): 69—74. PMID 12074842. doi:10.1016/S0168-0102(02)00018-4.
Kaur B, Brat DJ, Calkins CC, Van Meir EG (2003). „Brain Angiogenesis Inhibitor 1 Is Differentially Expressed in Normal Brain and Glioblastoma Independently of p53 Expression”. Am. J. Pathol. 162 (1): 19—27. PMC 1851137 . PMID 12507886. doi:10.1016/S0002-9440(10)63794-7.
Adkins JN; Varnum SM; Auberry KJ; et al. (2003). „Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry”. Mol. Cell Proteomics. 1 (12): 947—55. PMID 12543931. doi:10.1074/mcp.M200066-MCP200.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
Koh JT; Kook H; Kee HJ; et al. (2004). „Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin”. Exp. Cell Res. 294 (1): 172—84. PMID 14980512. doi:10.1016/j.yexcr.2003.11.008.
Bjarnadóttir TK; Fredriksson R; Höglund PJ; et al. (2005). „The human and mouse repertoire of the adhesion family of G-protein-coupled receptors”. Genomics. 84 (1): 23—33. PMID 15203201. doi:10.1016/j.ygeno.2003.12.004.

[pmid9533023-1] Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (1998). „Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)”. Cytogenet Cell Genet. 79 (1–2): 103—8. PMID 9533023. doi:10.1159/000134693.

[entrez-2] а ^б „Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1”.

[pmid9790924-3] Shiratsuchi, T; Oda K; et al. (1998). „Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1”. Biochem. Biophys. Res. Commun. UNITED STATES. 251 (1): 158—65. ISSN 0006-291X. PMID 9790924. doi:10.1006/bbrc.1998.9408.

[pmid9647739-4] Shiratsuchi, T; Futamura M; et al. (1998). „Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1”. Biochem. Biophys. Res. Commun. UNITED STATES. 247 (3): 597—604. ISSN 0006-291X. PMID 9647739. doi:10.1006/bbrc.1998.8603.

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