TAAR6

Trag amin-asocirani receptor 6
Trag amin-asocirani receptor 6
Identifikatori
Simboli	TAAR6; RP11-295F4.3; TA4; TAR4; TAR6; TRAR4; taR-4; taR-6
Vanjski ID	OMIM: 608923 MGI: 2685074 HomoloGene: 27874 IUPHAR: TAAR6 GeneCards: TAAR6 Gene
Ontologija gena
Molekularna funkcija	• aktivnost prenosa signala; • receptorska aktivnost; • aktivnost G-protein spregnutog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa membranom;
Biološki proces	• signalni put G-protein spregnutog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	319100
Ensembl	ENSG00000146383
UniProt	Q96RI8
RefSeq (mRNA)	NM_175067.1
RefSeq (protein)	NP_778237.1
Lokacija (UCSC)	Chr 6:; 132.89 - 132.89 Mb
PubMed pretraga	[1]

Trag amin-asocirani receptor 6 (TAAR6) je protein koji je kod ljudi kodiran TAAR6 genom.^[1]^[2]

Funkcija

TAAR6 pripada familiji trag amin-asociranih receptora. Trag amini su endogena aminska jedinjenja koja su hemijski slična sa klasičnim biogenim aminima poput dopamina, norepinefrina, serotonina, i histamina. Trag amini su ranije smatrani 'lažnim transmiterima' koji istiskuju klasične biogene amine iz njihovih skladišta i deluju na transportere na način sličan amfetaminima. Identifikacija moždanih receptora koji su specifični za trag amine ukazuje na činjenicu da oni isto tako samostalno deluju.^[3]^[4]

Reference

^ Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (2001). „Trace amines: identification of a family of mammalian G protein-coupled receptors”. Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966—71. PMC 55357 . PMID 11459929. doi:10.1073/pnas.151105198.
^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (2005). „Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors”. Genomics. 85 (3): 372—85. PMID 15718104. doi:10.1016/j.ygeno.2004.11.010.
^ Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV (2004). „Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia”. Am. J. Hum. Genet. 75 (4): 624—38. PMC 1182049 . PMID 15329799. doi:10.1086/424887.
^ „Entrez Gene: TAAR6 trace amine associated receptor 6”.

Literatura

Cao Q; Martinez M; Zhang J; et al. (1997). „Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees.”. Genomics. 43 (1): 1—8. PMID 9226366. doi:10.1006/geno.1997.4815.
Kaufmann CA; Suarez B; Malaspina D; et al. (1998). „NIMH Genetics Initiative Millennium Schizophrenia Consortium: linkage analysis of African-American pedigrees.”. Am. J. Med. Genet. 81 (4): 282—9. PMID 9674972. doi:10.1002/(SICI)1096-8628(19980710)81:4<282::AID-AJMG2>3.0.CO;2-W.
Borowsky B; Adham N; Jones KA; et al. (2001). „Trace amines: identification of a family of mammalian G protein-coupled receptors.”. Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966—71. PMC 55357 . PMID 11459929. doi:10.1073/pnas.151105198.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Mungall AJ; Palmer SA; Sims SK; et al. (2003). „The DNA sequence and analysis of human chromosome 6.”. Nature. 425 (6960): 805—11. PMID 14574404. doi:10.1038/nature02055.
Duan J; Martinez M; Sanders AR; et al. (2004). „Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia.”. Am. J. Hum. Genet. 75 (4): 624—38. PMC 1182049 . PMID 15329799. doi:10.1086/424887.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Lindemann L; Ebeling M; Kratochwil NA; et al. (2005). „Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.”. Genomics. 85 (3): 372—85. PMID 15718104. doi:10.1016/j.ygeno.2004.11.010.
Amann D; Avidan N; Kanyas K; et al. (2006). „The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23.”. Mol. Psychiatry. 11 (2): 119—21. PMID 16189505. doi:10.1038/sj.mp.4001752.

[pmid11459929-1] Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (2001). „Trace amines: identification of a family of mammalian G protein-coupled receptors”. Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966—71. PMC 55357 . PMID 11459929. doi:10.1073/pnas.151105198.

[pmid15718104-2] Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (2005). „Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors”. Genomics. 85 (3): 372—85. PMID 15718104. doi:10.1016/j.ygeno.2004.11.010.

[pmid15329799-3] Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV (2004). „Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia”. Am. J. Hum. Genet. 75 (4): 624—38. PMC 1182049 . PMID 15329799. doi:10.1086/424887.

[entrez-4] „Entrez Gene: TAAR6 trace amine associated receptor 6”.

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