Tetrahidrokanabinolna kiselina

Tetrahidrokanabinolna kiselina
IUPAC ime
(6aR,10aR)-1-hidroksi-6,6,9-trimetil-3-pentil-6a,7,8,10a-tetrahidro-6h-benzo[c]hromen-2-karboksilna kiselina
Identifikatori
CAS broj23978-85-0 ДаY
ATC kodnone
PubChemCID 98523
ChemSpider88974
Hemijski podaci
FormulaC22H30O4
Molarna masa358,4733 g/mol
  • CCCCCC1=CC2=C([C@@H]3C=C(CC[C@H]3C(O2)(C)C)C)C(=C1C(=O)O)O

Tetrahidrokanabinolna kiselina (THCA, 2-COOH-THC) je biosintetički precursor tetrahidrokanabinola (THC), aktivne komponente kanabisa.[1][2][3][4] THCA je prisutan u varijabilnim količinama u svežem, neosušenom kanabisu, ali se progresiivno dekarboksiluje do THC tokom sušenja, a posebno tokom intezivnog zagrevanja, npr. pri pušenju kanabisa.[5]

Reference

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  1. ^ Baker PB, Taylor BJ, Gough TA (1981), „The tetrahydrocannabinol and tetrahydrocannabinolic acid content of cannabis products”, Journal of Pharmacy and Pharmacology, 33 (6): 369—72, PMID 6115009 
  2. ^ Sirikantaramas S, Morimoto S, Shoyama Y, Ishikawa Y, Wada Y, Shoyama Y, Taura F (17. 9. 2004), „The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Delta1-tetrahydrocannabinolic acid synthase from Cannabis sativa L.”, Journal of Biological Chemistry, 279 (38): 39767—74, PMID 15190053 
  3. ^ Moore C, Rana S, Coulter C (1. 6. 2007), „Simultaneous identification of 2-carboxy-tetrahydrocannabinol, tetrahydrocannabinol, cannabinol and cannabidiol in oral fluid”, J Chromatogr B Analyt Technol Biomed Life Sci., 852 (1-2): 459—64, PMID 17321807 
  4. ^ Taura F. (2009), „Studies on tetrahydrocannabinolic acid synthase that produces the acidic precursor of tetrahydrocannabinol, the pharmacologically active cannabinoid in marijuana”, Drug Discoveries and Therapeutics, 3 (3): 83—7, PMID 22495534 
  5. ^ Dussy FE, Hamberg C, Luginbühl M, Schwerzmann T, Briellmann TA (2005-04-20), „Isolation of Delta9-THCA-A from hemp and analytical aspects concerning the determination of Delta9-THC in cannabis products”, Forensic Science International, 149 (1): 3—10, PMID 15734104 

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