NEUROD1

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NEUROD1
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 2QL2
識別號
别名	NEUROD1；, BETA2, BHF-1, MODY6, NEUROD, bHLHa3, neuronal differentiation 1, T2D
外部ID	OMIM：601724 MGI：1339708 HomoloGene：1871 GeneCards：NEUROD1
基因位置（人类） 染色体 2號染色體[1] 基因座 2q31.3 起始 181,668,295 bp[1] 终止 181,680,827 bp[1]
基因位置（小鼠） 染色体 小鼠2号染色体[2] 基因座 2 C3|2 47.58 cM 起始 79,282,865 bp[2] 终止 79,287,095 bp[2]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • sequence-specific DNA binding • 转录共激活因子活性 • DNA结合 • protein dimerization activity • DNA结合转录因子活性 • DNA-binding transcription activator activity, RNA polymerase II-specific • 转录因子结合 • chromatin binding • RNA polymerase II cis-regulatory region sequence-specific DNA binding • E-box binding • 血浆蛋白结合 • protein heterodimerization activity • double-stranded DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific 細胞組分 • 細胞質 • 胞內 • 核质 • RNA polymerase II transcription regulator complex • 细胞核 生物學過程 • positive regulation of transcription regulatory region DNA binding • regulation of neuron differentiation • 神经发生 • 细胞分化 • cell fate commitment • regulation of transcription, DNA-templated • pancreatic PP cell fate commitment • glucose homeostasis • regulation of insulin secretion • enteroendocrine cell differentiation • dentate gyrus development • signal transduction involved in regulation of gene expression • neuron development • insulin secretion • positive regulation of DNA-binding transcription factor activity • response to glucose • transcription by RNA polymerase II • embryonic organ morphogenesis • cerebellum development • transcription, DNA-templated • 神經系統的發育 • positive regulation of transcription, DNA-templated • multicellular organism development • hindbrain development • nucleocytoplasmic transport • positive regulation of neuron differentiation • positive regulation of cell differentiation • nitric oxide mediated signal transduction • positive regulation of apoptotic process • regulation of intestinal epithelial structure maintenance • 内耳的发生 • camera-type eye development • pancreatic A cell fate commitment • amacrine cell differentiation • negative regulation of type B pancreatic cell apoptotic process • cellular response to glucose stimulus • anterior/posterior pattern specification • endocrine pancreas development • positive regulation of transcription by RNA polymerase II • negative regulation of receptor signaling pathway via JAK-STAT Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	4760	18012
Ensembl	ENSG00000162992	ENSMUSG00000034701
UniProt	Q13562	Q60867
mRNA​序列	NM_002500	NM_010894
蛋白序列	NP_002491	NP_035024
基因位置​（UCSC）	Chr 2: 181.67 – 181.68 Mb	Chr 2: 79.28 – 79.29 Mb
PubMed​查找	[3]	[4]
維基數據
檢視/編輯人類 檢視/編輯小鼠

NEUROD1，（小鼠的同源蛋白質記爲NeuroD1）在人體內是NeuroD蛋白家族下的一個轉錄因子，由NEUROD1基因編碼。NEUROD1在神經系統發育中扮演重要角色，於發育中參與調控多種神經系細胞的分化過程^[5][6]。

證據表明NEUROD1與II型糖尿病的發生關係密切^[7]。一項研究表明在小鼠大腦內過表達NEUROD1可使神經膠質細胞轉分化爲神經元^[8]。

蛋白质相互作用

已知NEUROD1会和周期蛋白D1^[9]、MAFA^[10]、MAP3K10^[11]发生相互作用。

參考

1. GRCh38: Ensembl release 89: ENSG00000162992 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034701 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
5. Poulin, G; Turgeon, B; Drouin, J. NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Molecular and Cellular Biology. 1997-11, 17 (11): 6673–6682 [2021-11-10]. ISSN 0270-7306. PMC 232521 . PMID 9343431. doi:10.1128/MCB.17.11.6673. （原始内容存档于2021-11-10） （英语）. 
6. NEUROD1. UniProt. [2018-02-25]. （原始内容存档于2018-02-25）. 
7. NEUROD1 neuronal differentiation 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）. 
8. Guo, Ziyuan; Zhang, Lei; Wu, Zheng; Chen, Yuchen; Wang, Fan; Chen, Gong. In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model. Cell Stem Cell. 2014-02, 14 (2): 188–202 [2021-11-10]. PMC 3967760 . PMID 24360883. doi:10.1016/j.stem.2013.12.001. （原始内容存档于2022-02-17） （英语）. 
9. Ratineau, Christelle; Petry, Mary W.; Mutoh, Hiroyuki; Leiter, Andrew B. Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. The Journal of Biological Chemistry. 2002-03-15, 277 (11): 8847–8853 [2021-11-10]. ISSN 0021-9258. PMID 11788592. doi:10.1074/jbc.M110747200. （原始内容存档于2021-11-10）. 
10. Zhao, Li; Guo, Min; Matsuoka, Taka-Aki; Hagman, Derek K.; Parazzoli, Susan D.; Poitout, Vincent; Stein, Roland. The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. The Journal of Biological Chemistry. 2005-03-25, 280 (12): 11887–11894 [2021-11-10]. ISSN 0021-9258. PMID 15665000. doi:10.1074/jbc.M409475200. （原始内容存档于2022-04-19）. 
11. Marcora, E.; Gowan, K.; Lee, J. E. Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2. Proceedings of the National Academy of Sciences. 2003-08-05, 100 (16): 9578–9583. ISSN 0027-8424. PMC 170960 . PMID 12881483. doi:10.1073/pnas.1133382100 （英语）.