Chiniofon

Chiniofon
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	P01AX01 (WHO) QP51AX01 (WHO);
Identifiers
	IUPAC name 8-Hydroxy-7-iodo-5-quinolinesulfonic acid;
CAS Number	8002-90-2;
PubChem CID	11043;
DrugBank	DB13379 ;
ChemSpider	10575 ;
UNII	98F8Y85B6W;
ChEMBL	ChEMBL2104146;
CompTox Dashboard (EPA)	DTXSID1046136 ;
ECHA InfoCard	100.008.127
Chemical and physical data
Formula	C9H6INO4S
Molar mass	351.11 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(O)c1cc(I)c(O)c2ncccc12;
	InChI InChI=1S/C9H6INO4S/c10-6-4-7(16(13,14)15)5-2-1-3-11-8(5)9(6)12/h1-4,12H,(H,13,14,15) ; Key:ZBJWWKFMHOAPNS-UHFFFAOYSA-N ;
	(verify)

Chiniofon (Quiniofon, HIQSA, Loretin, Ferron) is an antiprotozoal agent.^[1]

Synthesis

The chemical synthesis of chiniofon has been reported:^[2]^[3]^[4]^[5] It is made from 8-hydroxyquinoline starting material.

^ "Chiniofon". WHO Collaborating Centre for Drug Statistics Methodology.
^ Majidian, M., Raoof, J. B., Hosseini, S. R., Fischer, J., Barek, J. (February 2020). "Determination of 8-hydroxy-7-iodo-5-quinoline sulfonic acid (HIQSA) at renewable electrode with Sb2O3/MWCNT-TiO2 nanohybrid". Journal of Electroanalytical Chemistry. 858 113775. doi:10.1016/j.jelechem.2019.113775. ISSN 1572-6657. Retrieved 30 August 2026.
^ Claus, Ad. (January 1893). "m‐Jod‐o‐oxychinolin‐ana‐sulfonsäure (Loretin) ein neues Antiseptikum zum Ersatz des Jodoforms". Archiv der Pharmazie. 231 (9): 704–715. doi:10.1002/ardp.18932310913. Retrieved 30 August 2026.
^ Cohn, G. (16 December 1911). "Zur Kenntnis des o‐Oxychinolins". Journal für Praktische Chemie. 83 (1): 498–506. doi:10.1002/prac.19110830136. ISSN 0021-8383. Retrieved 30 August 2026.
^ Gershon, H., McNeil, M. W. (November 1971). "8-Quinolinol sulfonic acids". The Journal of Organic Chemistry. 36 (23): 3494–3496. doi:10.1021/jo00822a005. Retrieved 30 August 2026.