FOXP4

FOXP4
Identifiers
Aliases	FOXP4, hFKHLA, forkhead box P4
External IDs	OMIM: 608924; MGI: 1921373; HomoloGene: 12536; GeneCards: FOXP4; OMA:FOXP4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 41,546,381 bp[1] End 41,602,384 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 48,178,058 bp[2] End 48,235,570 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pylorus body of stomach cardia cardiac muscle tissue of right atrium ganglionic eminence fundus popliteal artery tibial arteries right coronary artery myocardium of left ventricle Top expressed in sphenoid bone genital tubercle lesser wing of sphenoid bone basisphenoid ganglionic eminence yolk sac ventricular zone urinary bladder primary visual cortex cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II anatomical structure morphogenesis cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116113 74123 Ensembl ENSG00000137166 ENSMUSG00000023991 UniProt Q8IVH2 Q9DBY0 RefSeq (mRNA) NM_001012426 NM_001012427 NM_138457 NM_001405824 NM_001405825 NM_001405826 NM_001110824 NM_001110825 NM_028767 RefSeq (protein) NP_001012426 NP_001012427 NP_612466 NP_001104294 NP_001104295 NP_083043 NP_001390898 NP_001390899 Location (UCSC) Chr 6: 41.55 – 41.6 Mb Chr 17: 48.18 – 48.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.^[5]

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.^[5] It also is a major factor in developing Long COVID as such, increasing the chances of developing the little-understood syndrome 1.6 fold, a finding which has major implications for COVID-19 pandemic research.^[6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000137166 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023991 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FOXP4 forkhead box P4".
6. Ledford H (July 2023). "Gene linked to long COVID found in analysis of thousands of patients". Nature. 619 (7970): 445. Bibcode:2023Natur.619..445L. doi:10.1038/d41586-023-02269-2. PMID 37433943. S2CID 259831412.
7. Lammi V, Nakanishi T, Jones SE, Andrews SJ, Karjalainen J, Cortés B, et al. (June 2025). "Genome-wide association study of long COVID". Nature Genetics. 57 (6): 1402–1417. doi:10.1038/s41588-025-02100-w. PMC 12165857. PMID 40399555.

Further reading

• Katoh M, Katoh M (2005). "Human FOX gene family (Review)". International Journal of Oncology. 25 (5): 1495–1500. doi:10.3892/ijo.25.5.1495. PMID 15492844.
• Lu MM, Li S, Yang H, Morrisey EE (2003). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Gene Expression Patterns. 2 (3–4): 223–228. doi:10.1016/S1567-133X(02)00058-3. PMID 12617805. (Retracted, see doi:10.1016/S0925-4773(03)00085-6)
• Teufel A, Wong EA, Mukhopadhyay M, Malik N, Westphal H (June 2003). "FoxP4, a novel forkhead transcription factor". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1627 (2–3): 147–152. doi:10.1016/S0167-4781(03)00074-5. PMID 12818433.
• Lu MM, Li S, Yang H, Morrisey EE (2002). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Mechanisms of Development. 119 (Suppl 1): S197–202. doi:10.1016/S0925-4773(03)00116-3. PMID 14516685. S2CID 935988.
• Li S, Weidenfeld J, Morrisey EE (2004). "Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions". Molecular and Cellular Biology. 24 (2): 809–822. doi:10.1128/MCB.24.2.809-822.2004. PMC 343786. PMID 14701752.
• Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, et al. (September 2006). "Transcriptional genomics associates FOX transcription factors with human heart failure". Circulation. 114 (12): 1269–1276. doi:10.1161/CIRCULATIONAHA.106.632430. PMID 16952980.