CCL7

Hemokin (C-C motiv) ligand 7
	; PDB prikaz baziran na 1bo0.
Dostupne strukture
	1bo0, 1ncv
Identifikatori
Simboli	CCL7; FIC; MARC; MCP-3; MCP3; MGC138463; MGC138465; NC28; SCYA7
Vanjski ID	OMIM: 158106 MGI: 99512 HomoloGene: 4568 GeneCards: CCL7 Gene
Ontologija gena
Molekularna funkcija	• hemokinska aktivnost • vezivanje heparina
Celularna komponenta	• ekstracelularni region • ekstracelularni prostor
Biološki proces	• ćelijska homeostaza kalcijum jona • hemotaksa • inflamatorni odgovor • imunski odgovor • transdukcija signala • interćelijska signalizacija • antimikrobni humoralni respons
Pregled RNK izražavanja
	podaci
Ortolozi

edit

CCL7, hemokin (C-C motiv) ligand 7 je mali citokin. Ovaj hemokin se ranije zvao monocit-specifični hemokin 3 (MCP3). Pošto CCL7 poseduje dva susedna N-terminalna cisteinska ostatka u svom završnom obliku, on je klasifikovan u potfamiliju hemokina poznatih kao CC hemokini. CCL7 specifično privlači monocite, i reguliše makrofagne funkcije. Njega proizvode određene tumorske ćelijske linije i makrofage.^[1] Ovaj hemokin je lociran na hromozomu 17 kod ljudi, u velikom klasteru koji sadrži mnoge druge CC hemokine^[2]. On je srodan sa hemokinom CCL2 (koji se ranije zvao MCP1).^[3]

Interakcije

Za CCL7 je bilo pokazano da interaguje sa MMP2.^[4]

Reference

↑ Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J (1993). „Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines”. Biochem. Biophys. Res. Commun. 191 (2): 535–42. DOI:10.1006/bbrc.1993.1251. PMID 8461011.
↑ Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J (1994). „The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12”. Genomics 21 (2): 403–8. DOI:10.1006/geno.1994.1283. PMID 7916328.
↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
↑ McQuibban, G A; Gong J H, Tam E M, McCulloch C A, Clark-Lewis I, Overall C M (August 2000). „Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3”. Science (UNITED STATES) 289 (5482): 1202–6. ISSN 0036-8075. PMID 10947989.

Literatura

Menten P, Wuyts A, Van Damme J (2002). „Monocyte chemotactic protein-3.”. Eur. Cytokine Netw. 12 (4): 554–60. PMID 11781181.
Van Damme J, Proost P, Lenaerts JP, Opdenakker G (1992). „Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.”. J. Exp. Med. 176 (1): 59–65. DOI:10.1084/jem.176.1.59. PMC 2119277. PMID 1613466.
Ben-Baruch A, Xu L, Young PR, et al. (1995). „Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3.”. J. Biol. Chem. 270 (38): 22123–8. PMID 7545673.
Opdenakker G, Fiten P, Nys G, et al. (1994). „The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.”. Genomics 21 (2): 403–8. DOI:10.1006/geno.1994.1283. PMID 7916328.
Minty A, Chalon P, Guillemot JC, et al. (1993). „Molecular cloning of the MCP-3 chemokine gene and regulation of its expression.”. Eur. Cytokine Netw. 4 (2): 99–110. PMID 8318676.
Opdenakker G, Froyen G, Fiten P, et al. (1993). „Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines.”. Biochem. Biophys. Res. Commun. 191 (2): 535–42. DOI:10.1006/bbrc.1993.1251. PMID 8461011.
Combadiere C, Ahuja SK, Van Damme J, et al. (1996). „Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B.”. J. Biol. Chem. 270 (50): 29671–5. DOI:10.1074/jbc.270.50.29671. PMID 8530354.
Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). „Chemokine and chemokine receptor mRNA expression in human platelets.”. Cytokine 7 (6): 479–82. DOI:10.1006/cyto.1995.0065. PMID 8580362.
Daugherty BL, Siciliano SJ, DeMartino JA, et al. (1996). „Cloning, expression, and characterization of the human eosinophil eotaxin receptor.”. J. Exp. Med. 183 (5): 2349–54. DOI:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.
Kim KS, Rajarathnam K, Clark-Lewis I, Sykes BD (1996). „Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3.”. FEBS Lett. 395 (2-3): 277–82. DOI:10.1016/0014-5793(96)01024-1. PMID 8898111.
Meunier S, Bernassau JM, Guillemot JC, et al. (1997). „Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy.”. Biochemistry 36 (15): 4412–22. DOI:10.1021/bi9627929. PMID 9109648.
Polentarutti N, Introna M, Sozzani S, et al. (1997). „Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells.”. Eur. Cytokine Netw. 8 (3): 271–4. PMID 9346360.
Bonini JA, Martin SK, Dralyuk F, et al. (1997). „Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.”. DNA Cell Biol. 16 (10): 1249–56. DOI:10.1089/dna.1997.16.1249. PMID 9364936.
Nibbs RJ, Wylie SM, Yang J, et al. (1998). „Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.”. J. Biol. Chem. 272 (51): 32078–83. DOI:10.1074/jbc.272.51.32078. PMID 9405404.
Wang JM, Ueda H, Howard OM, et al. (1998). „HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.”. J. Immunol. 161 (8): 4309–17. PMID 9780207.
Albini A, Ferrini S, Benelli R, et al. (1998). „HIV-1 Tat protein mimicry of chemokines.”. Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13153–8. DOI:10.1073/pnas.95.22.13153. PMC 23742. PMID 9789057.
Rabin RL, Park MK, Liao F, et al. (1999). „Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling.”. J. Immunol. 162 (7): 3840–50. PMID 10201901.
Wedemeyer J, Lorentz A, Göke M, et al. (1999). „Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa.”. Gut 44 (5): 629–35. PMC 1727483. PMID 10205198.
Blanpain C, Migeotte I, Lee B, et al. (1999). „CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.”. Blood 94 (6): 1899–905. PMID 10477718.
Jordan NJ, Kolios G, Abbot SE, et al. (1999). „Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells.”. J. Clin. Invest. 104 (8): 1061–9. DOI:10.1172/JCI6685. PMC 408573. PMID 10525044.

Vanjske veze

CCL7 GeneCard

[pmid8461011-1] Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J (1993). „Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines”. Biochem. Biophys. Res. Commun. 191 (2): 535–42. DOI:10.1006/bbrc.1993.1251. PMID 8461011.

[pmid7916328-2] Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J (1994). „The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12”. Genomics 21 (2): 403–8. DOI:10.1006/geno.1994.1283. PMID 7916328.

[3] Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[pmid10947989-4] McQuibban, G A; Gong J H, Tam E M, McCulloch C A, Clark-Lewis I, Overall C M (August 2000). „Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3”. Science (UNITED STATES) 289 (5482): 1202–6. ISSN 0036-8075. PMID 10947989.

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