Takalcitol

Takalcitol
(IUPAC) ime
	(1S,3R,5Z,7E,24R)-9,10-sekoholesta-5,7,10-trien-1,3,24-triol
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	57333-96-7
ATC kod	D05AX04
PubChem	5283734
UNII	C2W72OJ5ZU
ChEMBL	CHEMBL340361
Hemijski podaci
Formula	C27H44O3
Mol. masa	416,64
InChI
	InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1 ; Key: BJYLYJCXYAMOFT-RSFVBTMBSA-N
Sinonimi	(1α,24R)-1,24-Dihidroksivitamin D3
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	Topikalno

Takalcitol (1,24-dihidroksivitamin D₃) je sintetički analog vitamina D₃.^[4] Takalcitol je u prodaji pod mnoštvom naziva, uključujući Curatoderm i Bonalfa.

Mehanizam

Takalcitol redukuje prekomerni obrt ćelija u pokožici putem interakcije sa receptorima vitamina D na keratinocitima.

Upotreba

On se koristi za tretman psorijaze, hronično ispucalih usni i drugih stanja prekomerno suve kože zbog njegove sposobnosti da redukuje prekomerni obrt ćelija kože. On je dostupan u obliku ulja i losiona.

On se takođe koristi za vitiligo^[5] i Hejli-Hejli bolest.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Fukuoka M, Sakurai K, Ohta T, Kiyoki M, Katayama I (2001). „Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes”. Skin Pharmacol. Appl. Skin Physiol. 14 (4): 226–33. DOI:10.1159/000056351. PMID 11464105.
↑ Leone G, Pacifico A, Iacovelli P, Paro Vidolin A, Picardo M (March 2006). „Tacalcitol and narrow-band phototherapy in patients with vitiligo”. Clin. Exp. Dermatol. 31 (2): 200–5. DOI:10.1111/j.1365-2230.2005.02037.x. PMID 16487090. Arhivirano iz originala na datum 2013-01-05. Pristupljeno 2014-04-05.
↑ Aoki T, Hashimoto H, Koseki S, Hozumi Y, Kondo S (November 1998). „1alpha,24-dihydroxyvitamin D3 (tacalcitol) is effective against Hailey-Hailey disease both in vivo and in vitro”. Br. J. Dermatol. 139 (5): 897–901. DOI:10.1046/j.1365-2133.1998.02522.x. PMID 9892963. Arhivirano iz originala na datum 2013-01-05. Pristupljeno 2014-04-05.

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid11464105-4] Fukuoka M, Sakurai K, Ohta T, Kiyoki M, Katayama I (2001). „Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes”. Skin Pharmacol. Appl. Skin Physiol. 14 (4): 226–33. DOI:10.1159/000056351. PMID 11464105.

[pmid16487090-5] Leone G, Pacifico A, Iacovelli P, Paro Vidolin A, Picardo M (March 2006). „Tacalcitol and narrow-band phototherapy in patients with vitiligo”. Clin. Exp. Dermatol. 31 (2): 200–5. DOI:10.1111/j.1365-2230.2005.02037.x. PMID 16487090. Arhivirano iz originala na datum 2013-01-05. Pristupljeno 2014-04-05.

[pmid9892963-6] Aoki T, Hashimoto H, Koseki S, Hozumi Y, Kondo S (November 1998). „1alpha,24-dihydroxyvitamin D3 (tacalcitol) is effective against Hailey-Hailey disease both in vivo and in vitro”. Br. J. Dermatol. 139 (5): 897–901. DOI:10.1046/j.1365-2133.1998.02522.x. PMID 9892963. Arhivirano iz originala na datum 2013-01-05. Pristupljeno 2014-04-05.

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